@article{585882a4e8ed44a9a19aa8b02f9d4608,
title = "Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden",
abstract = "Background: Strength and mobility are essential for activities of daily living. With aging, weaker handgrip strength, mobility, and asymmetry predict poorer cognition. We therefore sought to quantify the relationship between handgrip metrics and volumes quantified on brain magnetic resonance imaging (MRI). Objective: To model the relationships between handgrip strength, mobility, and MRI volumetry. Methods: We selected 38 participants with Alzheimer's disease dementia: biomarker evidence of amyloidosis and impaired cognition. Handgrip strength on dominant and non-dominant hands was measured with a hand dynamometer. Handgrip asymmetry was calculated. Two-minute walk test (2MWT) mobility evaluation was combined with handgrip strength to identify non-frail versus frail persons. Brain MRI volumes were quantified with Neuroreader. Multiple regression adjusting for age, sex, education, handedness, body mass index, and head size modeled handgrip strength, asymmetry and 2MWT with brain volumes. We modeled non-frail versus frail status relationships with brain structures by analysis of covariance. Results: Higher non-dominant handgrip strength was associated with larger volumes in the hippocampus (p=0.02). Dominant handgrip strength was related to higher frontal lobe volumes (p=0.02). Higher 2MWT scores were associated with larger hippocampal (p=0.04), frontal (p=0.01), temporal (p=0.03), parietal (p=0.009), and occipital lobe (p=0.005) volumes. Frailty was associated with reduced frontal, temporal, and parietal lobe volumes. Conclusion: Greater handgrip strength and mobility were related to larger hippocampal and lobar brain volumes. Interventions focused on improving handgrip strength and mobility may seek to include quantified brain volumes on MR imaging as endpoints.",
keywords = "Brain volumes, handgrip, mobility, prevention",
author = "Somayeh Meysami and Raji, {Cyrus A.} and Glatt, {Ryan M.} and Popa, {Emily S.} and Ganapathi, {Aarthi S.} and Tess Bookheimer and Slyapich, {Colby B.} and Pierce, {Kyron P.} and Richards, {Casey J.} and Lampa, {Melanie G.} and Gill, {Jaya M.} and Rapozo, {Molly K.} and Hodes, {John F.} and Tongson, {Ynez M.} and Wong, {Claudia L.} and Mihae Kim and Porter, {Verna R.} and Kaiser, {Scott A.} and Panos, {Stella E.} and Dye, {Richelin V.} and Miller, {Karen J.} and Bookheimer, {Susan Y.} and Martin, {Neil A.} and Santosh Kesari and Kelly, {Daniel F.} and Bramen, {Jennifer E.} and Prabha Siddarth and Merrill, {David A.}",
note = "Funding Information: This work was supported by Providence St. Joseph Health, Seattle, WA [Alzheimer's Translational Pillar (ATP)]; Saint John's Health Center Foundation; Pacific Neuroscience Institute and Foundation, including the generous support of the Will and Cary Singleton as well as the McLoughlin family; and the National Institutes of Health [U01AG046139, RF1AG072637, RF1AG057443, U01AG061359, R01AG062514, R21AG061494]. Funding Information: We thank the patients and families that participated in this research, without which this work would not be possible. We would like to acknowledge Dr. Sarah McEwen for her assistance setting up the trial from which the study subjects were drawn for this report. This work was supported by Providence St. Joseph Health, Seattle, WA [Alzheimer{\textquoteright}s Translational Pillar (ATP)]; Saint John{\textquoteright}s Health Center Foundation; Pacific Neuroscience Institute and Foundation, including the generous support of the Will and Cary Singleton as well as the McLoughlin family; and the National Institutes of Health [U01AG046139, RF1AG072637, RF1AG057443, U01AG061359, R01AG062514, R21AG061494]. Dr. Raji is supported in his research by funding from the National Institutes of Health []. Publisher Copyright: {\textcopyright} 2023 - The authors. Published by IOS Press.",
year = "2023",
doi = "10.3233/JAD-220886",
language = "English",
volume = "91",
pages = "999--1006",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "3",
}