Handbook of prevention and Alzheimer's disease

Cyrus A. Raji, Yue Leng, J. Wesson Ashford, Dharma Singh Khalsa

Research output: Book/ReportBookpeer-review


It is almost 120 years since Alzheimer's disease (AD) was first reported, and the concept of modifiable risk factors associated with the disease has been present from the outset. Thus, the idea of preventing AD is not new, with reference to strategies noted as early as the 1990s. This subfield of AD research has matured in recent years, with the number of modifiable risk factors - the AD preventome - rising from the 7 initially identified to the current 12, with an estimated contribution to dementia cases worldwide of about 40%. This book, the Handbook of Prevention and Alzheimer's Disease, introduces physicians, scientists, and other stakeholders to this subfield of AD research. It investigates the AD preventome, which will continue to expand as the understanding of new factors and related biomarkers is refined. Optimizing this preventome leads to an improvement in overall brain health, an outcome which reduces the risk of developing AD and improves quality of life. The book goes on to examine other domains of prevention, from vascular risk factors to social engagement and from sleep health to spirituality. If the journey to end AD can be likened to a long and arduous challenge, understanding every possible part of the overall toolkit of approaches for disease prevention and intervention is essential. ogether with its companion volume on intervention, the book provides a comprehensive overview of strategies for tackling Alzheimer's disease, and will be of interest to all those working in the field.

Original languageEnglish
PublisherIOS Press
Number of pages658
ISBN (Electronic)9781643684932
ISBN (Print)9781643684925
StatePublished - Feb 20 2024


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