TY - JOUR
T1 - Halting the Effects of Flow Enhancement With Effective Intermittent Zeugmatographic Encoding (HEFEWEIZEN) in SSFP
AU - Derakhshan, Jamal J.
AU - Griswold, Mark A.
AU - Sunshine, Jeffrey L.
AU - Duerk, Jeffrey L.
PY - 2009/5
Y1 - 2009/5
N2 - Purpose: To describe a new method for performing dark blood (DB) magnetization preparation in TrueFISP (bSSFP) and apply the technique to high-resolution carotid artery imaging. Materials and Methods: The developed method (HEFE- WEIZEN) provides directional flow suppression, while pre- serving bSSFP contrast, by periodically applying spatial saturation in short repetition time (TR) TrueFISP. Steady- state free precession (SSFP) conditions are maintained throughout the acquisition for the imaging slice magneti- zation. HEFEWEIZEN was implemented on a 1.5 T scanner with standard receiver coils. Studies were performed in phantoms, eight asymptomatic volunteers, and two pa- tients with low- and high-grade carotid artery stenosis. Results: Average flow suppression was 88% 4% (arterial) and 85% 3% (venous) in a multislice study. Stationary signal, contrast, and fine details were maintained with only slight signal suppression (11% 11%). Comparison to dif- fusion-prepared SSFP in the common carotid artery dem- onstrated significant improvement in wall-lumen contrast- to-noise ratio efficiency (P 0.024). DB contrast was achieved with only 13% increased acquisition time (14.3 sec). Further acceleration was possible by confining the DB preparation to the central 60% of k-space. Conclusion: A fast, short TR, DB TrueFISP pulse sequence was developed and tested in the carotid arteries of asymp- tomatic volunteers and patients.
AB - Purpose: To describe a new method for performing dark blood (DB) magnetization preparation in TrueFISP (bSSFP) and apply the technique to high-resolution carotid artery imaging. Materials and Methods: The developed method (HEFE- WEIZEN) provides directional flow suppression, while pre- serving bSSFP contrast, by periodically applying spatial saturation in short repetition time (TR) TrueFISP. Steady- state free precession (SSFP) conditions are maintained throughout the acquisition for the imaging slice magneti- zation. HEFEWEIZEN was implemented on a 1.5 T scanner with standard receiver coils. Studies were performed in phantoms, eight asymptomatic volunteers, and two pa- tients with low- and high-grade carotid artery stenosis. Results: Average flow suppression was 88% 4% (arterial) and 85% 3% (venous) in a multislice study. Stationary signal, contrast, and fine details were maintained with only slight signal suppression (11% 11%). Comparison to dif- fusion-prepared SSFP in the common carotid artery dem- onstrated significant improvement in wall-lumen contrast- to-noise ratio efficiency (P 0.024). DB contrast was achieved with only 13% increased acquisition time (14.3 sec). Further acceleration was possible by confining the DB preparation to the central 60% of k-space. Conclusion: A fast, short TR, DB TrueFISP pulse sequence was developed and tested in the carotid arteries of asymp- tomatic volunteers and patients.
KW - Carotid stenosis
KW - Dark blood MRI
KW - Magnetization preparation
KW - Steady state free precession
KW - TrueFISP
KW - bSSFP
UR - http://www.scopus.com/inward/record.url?scp=66149094673&partnerID=8YFLogxK
U2 - 10.1002/jmri.21744
DO - 10.1002/jmri.21744
M3 - Article
C2 - 19388106
AN - SCOPUS:66149094673
SN - 1053-1807
VL - 29
SP - 1163
EP - 1174
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -