Hallmarks of a new era in mitochondrial biochemistry

David J. Pagliarini, Jared Rutter

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the "powerhouses" of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.

Original languageEnglish
Pages (from-to)2615-2627
Number of pages13
JournalGenes and Development
Volume27
Issue number24
DOIs
StatePublished - Dec 15 2013
Externally publishedYes

Keywords

  • Biochemistry
  • Mitochondria
  • Proteomics

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