Hairy cell Leukemia, Version 2.2018: Clinical practice guidelines in oncology

William G. Wierda, John C. Byrd, Jeremy S. Abramson, Seema Bhat, Greg Bociek, Danielle Brander, Jennifer Brown, Asher Chanan-Khan, Steve E. Coutre, Randall S. Davis, Christopher D. Fletcher, Brian Hill, Brad S. Kahl, Manali Kamdar, Lawrence D. Kaplan, Nadia Khan, Thomas J. Kipps, Jeffrey Lancet, Shuo Ma, Sami MalekClaudio Mosse, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Andrew D. Zelenetz

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Hairy cell leukemia (HCL) is a rare type of indolent B-cell leukemia, characterized by symptoms of fatigue and weakness, or-ganomegaly, pancytopenia, and recurrent opportunistic infections. Classic HCL should be considered a distinct clinical entity separate from HCLvariant (HCLv), which is associated with a more aggressive disease course and may not respond to standard HCL therapies. Somatic hypermutation in the IGHV gene is present in most patients with HCL. The BRAF V600E mutation has been reported in most patients with classic HCL but not in those with other B-cell leukemias or lymphomas. Therefore, it is necessary to distinguish HCLv from classic HCL. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of classic HCL.

Original languageEnglish
Pages (from-to)1414-1427
Number of pages14
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume15
Issue number11
DOIs
StatePublished - Nov 1 2017

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    Wierda, W. G., Byrd, J. C., Abramson, J. S., Bhat, S., Bociek, G., Brander, D., Brown, J., Chanan-Khan, A., Coutre, S. E., Davis, R. S., Fletcher, C. D., Hill, B., Kahl, B. S., Kamdar, M., Kaplan, L. D., Khan, N., Kipps, T. J., Lancet, J., Ma, S., ... Zelenetz, A. D. (2017). Hairy cell Leukemia, Version 2.2018: Clinical practice guidelines in oncology. JNCCN Journal of the National Comprehensive Cancer Network, 15(11), 1414-1427. https://doi.org/10.6004/jnccn.2017.0165