Haart improves prognosis in HIV-associated progressive multifocal leukoencephalopathy

David B. Clifford; C. Yiannoutsos; M. Glicksman; D. M. Simpson; E. J. Singer; P. J. Piliero; C. M. Marra; G. S. Francis; J. C. McArthur; K. L. Tyler; A. C. Tselis; N. E. Hyslop

doi:10.1212/wnl.52.3.623

Haart improves prognosis in HIV-associated progressive multifocal leukoencephalopathy

David B. Clifford, C. Yiannoutsos, M. Glicksman, D. M. Simpson, E. J. Singer, P. J. Piliero, C. M. Marra, G. S. Francis, J. C. McArthur, K. L. Tyler, A. C. Tselis, N. E. Hyslop

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239 Scopus citations

Abstract

Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV.

Original language	English
Pages (from-to)	623-625
Number of pages	3
Journal	Neurology
Volume	52
Issue number	3
DOIs	https://doi.org/10.1212/wnl.52.3.623
State	Published - Feb 1999

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title = "Haart improves prognosis in HIV-associated progressive multifocal leukoencephalopathy",

abstract = "Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV.",

author = "Clifford, {David B.} and C. Yiannoutsos and M. Glicksman and Simpson, {D. M.} and Singer, {E. J.} and Piliero, {P. J.} and Marra, {C. M.} and Francis, {G. S.} and McArthur, {J. C.} and Tyler, {K. L.} and Tselis, {A. C.} and Hyslop, {N. E.}",

year = "1999",

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doi = "10.1212/wnl.52.3.623",

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T1 - Haart improves prognosis in HIV-associated progressive multifocal leukoencephalopathy

AU - Clifford, David B.

AU - Yiannoutsos, C.

AU - Glicksman, M.

AU - Simpson, D. M.

AU - Singer, E. J.

AU - Piliero, P. J.

AU - Marra, C. M.

AU - Francis, G. S.

AU - McArthur, J. C.

AU - Tyler, K. L.

AU - Tselis, A. C.

AU - Hyslop, N. E.

PY - 1999/2

Y1 - 1999/2

N2 - Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV.

AB - Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV.

UR - http://www.scopus.com/inward/record.url?scp=0033017386&partnerID=8YFLogxK

U2 - 10.1212/wnl.52.3.623

DO - 10.1212/wnl.52.3.623

M3 - Article

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AN - SCOPUS:0033017386

SN - 0028-3878

VL - 52

SP - 623

EP - 625

JO - Neurology

JF - Neurology

IS - 3

ER -

Haart improves prognosis in HIV-associated progressive multifocal leukoencephalopathy

Abstract

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