TY - JOUR
T1 - GWAS of depression in 4,520 individuals from the Russian population highlights the role of MAGI2 (S-SCAM) in the gut-brain axis
AU - Pinakhina, Daria
AU - Yermakovich, Danat
AU - Vergasova, Ekaterina
AU - Kasyanov, Evgeny
AU - Rukavishnikov, Grigory
AU - Rezapova, Valeriia
AU - Kolosov, Nikita
AU - Sergushichev, Alexey
AU - Popov, Iaroslav
AU - Kovalenko, Elena
AU - Ilinskaya, Anna
AU - Kim, Anna
AU - Plotnikov, Nikolay
AU - Ilinsky, Valery
AU - Neznanov, Nikholay
AU - Mazo, Galina
AU - Kibitov, Alexander
AU - Rakitko, Alexander
AU - Artomov, Mykyta
N1 - Publisher Copyright:
Copyright © 2023 Pinakhina, Yermakovich, Vergasova, Kasyanov, Rukavishnikov, Rezapova, Kolosov, Sergushichev, Popov, Kovalenko, Ilinskaya, Kim, Plotnikov, Ilinsky, Neznanov, Mazo, Kibitov, Rakitko and Artomov.
PY - 2023/1/4
Y1 - 2023/1/4
N2 - We present the results of the depression Genome-wide association studies study performed on a cohort of Russian-descent individuals, which identified a novel association at chromosome 7q21 locus. Gene prioritization analysis based on already known depression risk genes indicated MAGI2 (S-SCAM) as the most probable gene from the locus and potential susceptibility gene for the disease. Brain and gut expression patterns were the main features highlighting functional relatedness of MAGI2 to the previously known depression risk genes. Local genetic covariance analysis, analysis of gene expression, provided initial suggestive evidence of hospital anxiety and depression scale and diagnostic and statistical manual of mental disorders scales having a different relationship with gut-brain axis disturbance. It should be noted, that while several independent methods successfully in silico validate the role of MAGI2, we were unable to replicate genetic association for the leading variant in the MAGI2 locus, therefore the role of rs521851 in depression should be interpreted with caution.
AB - We present the results of the depression Genome-wide association studies study performed on a cohort of Russian-descent individuals, which identified a novel association at chromosome 7q21 locus. Gene prioritization analysis based on already known depression risk genes indicated MAGI2 (S-SCAM) as the most probable gene from the locus and potential susceptibility gene for the disease. Brain and gut expression patterns were the main features highlighting functional relatedness of MAGI2 to the previously known depression risk genes. Local genetic covariance analysis, analysis of gene expression, provided initial suggestive evidence of hospital anxiety and depression scale and diagnostic and statistical manual of mental disorders scales having a different relationship with gut-brain axis disturbance. It should be noted, that while several independent methods successfully in silico validate the role of MAGI2, we were unable to replicate genetic association for the leading variant in the MAGI2 locus, therefore the role of rs521851 in depression should be interpreted with caution.
KW - GWAS
KW - HADS-D
KW - depression
KW - gene discovery
KW - gut brain axis
UR - http://www.scopus.com/inward/record.url?scp=85146482288&partnerID=8YFLogxK
U2 - 10.3389/fgene.2022.972196
DO - 10.3389/fgene.2022.972196
M3 - Article
C2 - 36685848
AN - SCOPUS:85146482288
SN - 1664-8021
VL - 13
JO - Frontiers in Genetics
JF - Frontiers in Genetics
M1 - 972196
ER -