TY - JOUR
T1 - Gut microbiota from twins discordant for obesity modulate metabolism in mice
AU - Ridaura, Vanessa K.
AU - Faith, Jeremiah J.
AU - Rey, Federico E.
AU - Cheng, Jiye
AU - Duncan, Alexis E.
AU - Kau, Andrew L.
AU - Griffin, Nicholas W.
AU - Lombard, Vincent
AU - Henrissat, Bernard
AU - Bain, James R.
AU - Muehlbauer, Michael J.
AU - Ilkayeva, Olga
AU - Semenkovich, Clay F.
AU - Funai, Katsuhiko
AU - Hayashi, David K.
AU - Lyle, Barbara J.
AU - Martini, Margaret C.
AU - Ursell, Luke K.
AU - Clemente, Jose C.
AU - Van Treuren, William
AU - Walters, William A.
AU - Knight, Rob
AU - Newgard, Christopher B.
AU - Heath, Andrew C.
AU - Gordon, Jeffrey I.
PY - 2013
Y1 - 2013
N2 - The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their corresponding fecal bacterial culture collections. Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cage mates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota and was diet-dependent. These findings reveal transmissible, rapid, and modifiable effects of diet-by-microbiota interactions.
AB - The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their corresponding fecal bacterial culture collections. Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cage mates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota and was diet-dependent. These findings reveal transmissible, rapid, and modifiable effects of diet-by-microbiota interactions.
UR - http://www.scopus.com/inward/record.url?scp=84883478660&partnerID=8YFLogxK
U2 - 10.1126/science.1241214
DO - 10.1126/science.1241214
M3 - Article
C2 - 24009397
AN - SCOPUS:84883478660
SN - 0036-8075
VL - 341
JO - Science
JF - Science
IS - 6150
M1 - 1241214
ER -