Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

on behalf of the NCER-PD Consortium

doi:10.1038/s41531-024-00687-1

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

on behalf of the NCER-PD Consortium

Division of Basic Science Research

Research output: Contribution to journal › Article › peer-review

Abstract

Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

Original language	English
Article number	78
Journal	npj Parkinson's Disease
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41531-024-00687-1
State	Published - Dec 2024

Access to Document

10.1038/s41531-024-00687-1

Cite this

@article{9345ec5b4d7e46ecb41f476fae189d7a,

title = "Gut microbiome is not associated with mild cognitive impairment in Parkinson{\textquoteright}s disease",

abstract = "Gut microbiome differences between people with Parkinson{\textquoteright}s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.",

author = "{on behalf of the NCER-PD Consortium} and Aho, {Velma T.E.} and Matthias Klee and Zied Landoulsi and Anna Heintz-Buschart and Lukas Pavelka and Leist, {Anja K.} and Rejko Kr{\"u}ger and Patrick May and Paul Wilmes and Geeta Acharya and Gloria Aguayo and Myriam Alexandre and Muhammad Ali and Wim Ammerlann and Giuseppe Arena and Michele Bassis and Roxane Batutu and Katy Beaumont and Sibylle B{\'e}chet and Guy Berchem and Alexandre Bisdorff and Ibrahim Boussaad and David Bouvier and Lorieza Castillo and Gessica Contesotto and {De Bremaeker}, Nancy and Brian Dewitt and Nico Diederich and Rene Dondelinger and Ramia, {Nancy E.} and Angelo Ferrari and Katrin Frauenknecht and Jo{\"e}lle Fritz and Carlos Gamio and Manon Gantenbein and Piotr Gawron and Laura Georges and Soumyabrata Ghosh and Marijus Giraitis and Enrico Glaab and Martine Goergen and {De Lope}, {Elisa G{\'o}mez} and J{\'e}r{\^o}me Graas and Mariella Graziano and Valentin Groues and Anne Gr{\"u}newald and Ga{\"e}l Hammot and Hanff, {Anne Marie} and Linda Hansen and Michael Heneka and Estelle Henry and Margaux Henry and Sylvia Herbrink and Sascha Herzinger and Alexander Hundt and Nadine Jacoby and Sonja J{\'o}nsd{\'o}ttir and Jochen Klucken and Olga Kofanova and Pauline Lambert and Roseline Lentz and Laura Longhino and Lopes, {Ana Festas} and Victoria Lorentz and Marques, {Tain{\'a} M.} and Guilherme Marques and Conde, {Patricia Martins} and Deborah Mcintyre and Chouaib Mediouni and Francoise Meisch and Alexia Mendibide and Myriam Menster and Maura Minelli and Michel Mittelbronn and Sa{\"i}da Mtimet and Maeva Munsch and Romain Nati and Ulf Nehrbass and Sarah Nickels and Beatrice Nicolai and Nicolay, {Jean Paul} and Fozia Noor and Gomes, {Clarissa P.C.} and Sinthuja Pachchek and Claire Pauly and Laure Pauly and Magali Perquin and Achilleas Pexaras and Armin Rauschenberger and Rajesh Rawal and Bobbili, {Dheeraj Reddy} and Lucie Remark and Ils{\'e} Richard and Olivia Roland and Kirsten Roomp and Eduardo Rosales and Stefano Sapienza and Venkata Satagopam and Sabine Schmitz and Reinhard Schneider and Jens Schwamborn and Raquel Severino and Amir Sharify and Ruxandra Soare and Ekaterina Soboleva and Kate Sokolowska and Maud Theresine and Hermann Thien and Elodie Thiry and Loo, {Rebecca Ting Jiin} and Johanna Trouet and Olena Tsurkalenko and Michel Vaillant and Carlos Vega and Boas, {Liliana Vilas} and Paul Wilmes and Evi Wollscheid-Lengeling and Gelani Zelimkhanov",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41531-024-00687-1",

language = "English",

volume = "10",

journal = "npj Parkinson's Disease",

issn = "2373-8057",

number = "1",

}

TY - JOUR

T1 - Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

AU - on behalf of the NCER-PD Consortium

AU - Aho, Velma T.E.

AU - Klee, Matthias

AU - Landoulsi, Zied

AU - Heintz-Buschart, Anna

AU - Pavelka, Lukas

AU - Leist, Anja K.

AU - Krüger, Rejko

AU - May, Patrick

AU - Wilmes, Paul

AU - Acharya, Geeta

AU - Aguayo, Gloria

AU - Alexandre, Myriam

AU - Ali, Muhammad

AU - Ammerlann, Wim

AU - Arena, Giuseppe

AU - Bassis, Michele

AU - Batutu, Roxane

AU - Beaumont, Katy

AU - Béchet, Sibylle

AU - Berchem, Guy

AU - Bisdorff, Alexandre

AU - Boussaad, Ibrahim

AU - Bouvier, David

AU - Castillo, Lorieza

AU - Contesotto, Gessica

AU - De Bremaeker, Nancy

AU - Dewitt, Brian

AU - Diederich, Nico

AU - Dondelinger, Rene

AU - Ramia, Nancy E.

AU - Ferrari, Angelo

AU - Frauenknecht, Katrin

AU - Fritz, Joëlle

AU - Gamio, Carlos

AU - Gantenbein, Manon

AU - Gawron, Piotr

AU - Georges, Laura

AU - Ghosh, Soumyabrata

AU - Giraitis, Marijus

AU - Glaab, Enrico

AU - Goergen, Martine

AU - De Lope, Elisa Gómez

AU - Graas, Jérôme

AU - Graziano, Mariella

AU - Groues, Valentin

AU - Grünewald, Anne

AU - Hammot, Gaël

AU - Hanff, Anne Marie

AU - Hansen, Linda

AU - Heneka, Michael

AU - Henry, Estelle

AU - Henry, Margaux

AU - Herbrink, Sylvia

AU - Herzinger, Sascha

AU - Hundt, Alexander

AU - Jacoby, Nadine

AU - Jónsdóttir, Sonja

AU - Klucken, Jochen

AU - Kofanova, Olga

AU - Lambert, Pauline

AU - Lentz, Roseline

AU - Longhino, Laura

AU - Lopes, Ana Festas

AU - Lorentz, Victoria

AU - Marques, Tainá M.

AU - Marques, Guilherme

AU - Conde, Patricia Martins

AU - Mcintyre, Deborah

AU - Mediouni, Chouaib

AU - Meisch, Francoise

AU - Mendibide, Alexia

AU - Menster, Myriam

AU - Minelli, Maura

AU - Mittelbronn, Michel

AU - Mtimet, Saïda

AU - Munsch, Maeva

AU - Nati, Romain

AU - Nehrbass, Ulf

AU - Nickels, Sarah

AU - Nicolai, Beatrice

AU - Nicolay, Jean Paul

AU - Noor, Fozia

AU - Gomes, Clarissa P.C.

AU - Pachchek, Sinthuja

AU - Pauly, Claire

AU - Pauly, Laure

AU - Perquin, Magali

AU - Pexaras, Achilleas

AU - Rauschenberger, Armin

AU - Rawal, Rajesh

AU - Bobbili, Dheeraj Reddy

AU - Remark, Lucie

AU - Richard, Ilsé

AU - Roland, Olivia

AU - Roomp, Kirsten

AU - Rosales, Eduardo

AU - Sapienza, Stefano

AU - Satagopam, Venkata

AU - Schmitz, Sabine

AU - Schneider, Reinhard

AU - Schwamborn, Jens

AU - Severino, Raquel

AU - Sharify, Amir

AU - Soare, Ruxandra

AU - Soboleva, Ekaterina

AU - Sokolowska, Kate

AU - Theresine, Maud

AU - Thien, Hermann

AU - Thiry, Elodie

AU - Loo, Rebecca Ting Jiin

AU - Trouet, Johanna

AU - Tsurkalenko, Olena

AU - Vaillant, Michel

AU - Vega, Carlos

AU - Boas, Liliana Vilas

AU - Wilmes, Paul

AU - Wollscheid-Lengeling, Evi

AU - Zelimkhanov, Gelani

PY - 2024/12

Y1 - 2024/12

N2 - Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

AB - Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

UR - http://www.scopus.com/inward/record.url?scp=85202152995&partnerID=8YFLogxK

U2 - 10.1038/s41531-024-00687-1

DO - 10.1038/s41531-024-00687-1

M3 - Article

C2 - 38582855

AN - SCOPUS:85202152995

SN - 2373-8057

VL - 10

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 78

ER -

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Abstract

Access to Document

Other files and links

Fingerprint

Cite this