@article{4ea966168fe2424b879fbe039a96f426,
title = "Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense",
abstract = "Extrinsic nociceptor neurons mediate protection from Salmonella infection by direct sensing and release of CGRP, which leads to suppression of M cell density and maintenance of SFB colonization of the ileum.",
keywords = "M cell, Peyer's patch, SFB, Salmonella, gut microbiome, host-pathogen, mucosal immunology, neuro-immune, nociceptor, segmentous filamentous bacteria",
author = "Lai, {Nicole Y.} and Musser, {Melissa A.} and Pinho-Ribeiro, {Felipe A.} and Pankaj Baral and Amanda Jacobson and Pingchuan Ma and Potts, {David E.} and Zuojia Chen and Donggi Paik and Salima Soualhi and Yiqing Yan and Aditya Misra and Kaitlin Goldstein and Lagomarsino, {Valentina N.} and Anja Nordstrom and Sivanathan, {Kisha N.} and Antonia Wallrapp and Kuchroo, {Vijay K.} and Roni Nowarski and Starnbach, {Michael N.} and Hailian Shi and Surana, {Neeraj K.} and Dingding An and Chuan Wu and Huh, {Jun R.} and Meenakshi Rao and Chiu, {Isaac M.}",
note = "Funding Information: We thank Neil Mabbott, Kathryn Knoop, Christophe Benoist, Nissan Yissachar, Michael Carroll, Muriel Larauche, Wendy Garrett, Gerald Pier, and Steve Liberles for helpful advice and Sebastien Sannajust, Wanyin Tao, Fabian Chavez Rivera, Jonathan Chang, Nicole Lee, Joseph Borrell, Chad Araneo, Alos Diallo, and Paula Montero Llopis for technical support. We thank Pablo Pereira for anti-Vγ7; Evegeni Sokurenko for ΔFimH STm; Andreas Baumler, Sebastian Winter, and Claire Bryant for Salmonella strains; Mark Hoon for Trpv1-DTR mice; and Mark Zylka for Calca-GFP-DTR mice. We thank Matthew Gudgeon and Tammy Hshieh. This work was supported by NIH ( DP2AT009499 to I.M.C.), NIAID ( R01AI130019 to I.M.C.), NIH ( R01DK110559 to J.R.H.), Chan‐Zuckerberg Initiative (I.M.C.), Harvard Digestive Disease Center ( NIDDK K08 DK110532 to M.R.), National Multiple Sclerosis Society Career Transition (award TA3059-A-2 to C.W.), NIH ( K08 AI108690 to N.K.S.), Whitehead Scholar , and Translating Duke Health Scholar (N.K.S.). Funding Information: We thank Neil Mabbott, Kathryn Knoop, Christophe Benoist, Nissan Yissachar, Michael Carroll, Muriel Larauche, Wendy Garrett, Gerald Pier, and Steve Liberles for helpful advice and Sebastien Sannajust, Wanyin Tao, Fabian Chavez Rivera, Jonathan Chang, Nicole Lee, Joseph Borrell, Chad Araneo, Alos Diallo, and Paula Montero Llopis for technical support. We thank Pablo Pereira for anti-V?7; Evegeni Sokurenko for ?FimH STm; Andreas Baumler, Sebastian Winter, and Claire Bryant for Salmonella strains; Mark Hoon for Trpv1-DTR mice; and Mark Zylka for Calca-GFP-DTR mice. We thank Matthew Gudgeon and Tammy Hshieh. This work was supported by NIH (DP2AT009499 to I.M.C.), NIAID (R01AI130019 to I.M.C.), NIH (R01DK110559 to J.R.H.), Chan?Zuckerberg Initiative (I.M.C.), Harvard Digestive Disease Center (NIDDK K08 DK110532 to M.R.), National Multiple Sclerosis Society Career Transition (award TA3059-A-2 to C.W.), NIH (K08 AI108690 to N.K.S.), Whitehead Scholar, and Translating Duke Health Scholar (N.K.S.). Planning and Conceptualization, N.Y.L. and I.M.C.; Experimentation and Data Analysis, N.Y.L. M.A.M. F.A.P.-R. P.B. A.J. P.M. H.S. D.E.P. Z.C. D.P. S.S. Y.Y. A.M. K.G. V.N.L. A.N. and K.N.S.; Provision of Key Resources, M.R. J.R.H. M.N.S. V.K.K. C.W. A.W. D.A. N.K.S. and R.N.; Writing Manuscript, N.Y.L. and I.M.C.; Editing Manuscript, N.Y.L. A.J. and I.M.C. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = jan,
day = "9",
doi = "10.1016/j.cell.2019.11.014",
language = "English",
volume = "180",
pages = "33--49.e22",
journal = "Cell",
issn = "0092-8674",
number = "1",
}