TY - JOUR
T1 - Gut-bladder axis enters the stage
T2 - Implication for recurrent urinary tract infections
AU - Salazar, Arnold M.
AU - Neugent, Michael L.
AU - De Nisco, Nicole J.
AU - Mysorekar, Indira U.
N1 - Funding Information:
This work was supported by NIH grants R01AG052494 , P20DK119840 , and R56AG064634 to I.U.M. as well as grants from the NIH ( 1R01DK131267 ) and the Welch Foundation ( AT-2030-20200401 ) to N.J.D. Figure 1 was created using BioRender. We thank Dr. Robert Lawrence for valuable comments and editing.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/8/10
Y1 - 2022/8/10
N2 - The gut microbiome is a critical modulator of systemic physiology, including infectious disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, knowledge of its role in urinary tract infections (UTIs) is limited. We discuss two recent studies, Thänert et al. (2022) and Worby et al. (2022), that interrogate the roles of the gut-bladder axis in UTIs.
AB - The gut microbiome is a critical modulator of systemic physiology, including infectious disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, knowledge of its role in urinary tract infections (UTIs) is limited. We discuss two recent studies, Thänert et al. (2022) and Worby et al. (2022), that interrogate the roles of the gut-bladder axis in UTIs.
UR - http://www.scopus.com/inward/record.url?scp=85135685806&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2022.07.008
DO - 10.1016/j.chom.2022.07.008
M3 - Comment/debate
C2 - 35952642
AN - SCOPUS:85135685806
SN - 1931-3128
VL - 30
SP - 1066
EP - 1069
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 8
ER -