Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

Laura V. Blanton, Mark R. Charbonneau, Tarek Salih, Michael J. Barratt, Siddarth Venkatesh, Olga Ilkaveya, Sathish Subramanian, Mark J. Manary, Indi Trehan, Josh M. Jorgensen, Yue Mei Fan, Bernard Henrissat, Semen A. Leyn, Dmitry A. Rodionov, Andrei L. Osterman, Kenneth M. Maleta, Christopher B. Newgard, Per Ashorn, Kathryn G. Dewey, Jeffrey I. Gordon

Research output: Contribution to journalArticlepeer-review

393 Scopus citations

Abstract

Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age- and growth-discriminatory taxa from the microbiota of the former were able to invade that of the latter, which prevented growth impairments in recipient animals. Adding two invasive species, Ruminococcus gnavus and Clostridium symbiosum, to the microbiota from undernourished donors also ameliorated growth and metabolic abnormalities in recipient animals. These results provide evidence that microbiota immaturity is causally related to undernutrition and reveal potential therapeutic targets and agents.

Original languageEnglish
Article numberaad3311
JournalScience
Volume351
Issue number6275
DOIs
StatePublished - Feb 19 2016

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