@article{a72089bf58b248a7806778a17699d4af,
title = "Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research",
abstract = "The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross-validation across cohorts and laboratories.",
keywords = "Alzheimer's disease, Biomarkers, Blood, Dementia, Diagnosis, Plasma, Serum, Treatment",
author = "O'Bryant, {Sid E.} and Veer Gupta and Kim Henriksen and Melissa Edwards and Andreas Jeromin and Simone Lista and Chantal Bazenet and Holly Soares and Simon Lovestone and Harald Hampel and Thomas Montine and Kaj Blennow and Tatiana Foroud and Maria Carrillo and Neill Graff-Radford and Christoph Laske and Monique Breteler and Leslie Shaw and Trojanowski, {John Q.} and Nicole Schupf and Rissman, {Robert A.} and Fagan, {Anne M.} and Pankaj Oberoi and Robert Umek and Weiner, {Michael W.} and Paula Grammas and Holly Posner and Ralph Martins",
note = "Funding Information: Sid E. O'Bryant has multiple patents pending, submitted by the University of North Texas Health Science Center wherein he is an inventor and receives research grants from the National Institutes of Health , National Institute on Aging , award number R01AG039389 and P30AG12300 . Veer Gupta reports no conflicts of interests. Kim Henriksen{\textquoteright}s research was supported by the Danish Research Foundation and reports no conflicts of interests. Melissa Edwards reports no conflicts of interests. Andreas Jeromin holds affiliations with Quanterix, Inc. and reports no conflict of interests. Chantal Bazenet reports no conflicts of interests. Holly Soares holds affiliations with Bristol-Myers Squibb and reports no conflicts of interests. Simon Lovestone reports no conflicts of interests. Harald Hampel is supported by the AXA Research Fund , the Fondation Universit{\'e} Pierre et Marie Curie , and the Fondation pour la Recherche sur Alzheimer , Paris, France. The research leading to these results has received funding from the program “Investissements d{\textquoteright}avenir” ANR-10-IAIHU-06. Thomas Montine receives funding from the National Institutes of Health , award Number P50AG05136 and reports no conflict of interest. Kaj Blennow has research supported by the Swedish Research Council , grant # 14002 , and has served on Advisory Boards for Innogenetics, Belgium. Tatiana Foroud reports no conflict of interest. Maria Carrillo reports no conflict of interest. Neill Graff-Radford reports no conflict of interest. Christoph Laske reports no conflict of interest. Monique Breteler reports no conflict of interest. Leslie Shaw reports no conflict of interest. John Q. Trojanowski may accrue revenue in the future on patents submitted by the University of Pennsylvania wherein he is co-Inventor and received revenue from the sale of Avid to Eli Lily as coinventor on imaging related patents submitted by the University of Pennsylvania. Nicole Schupf reports no conflicts of interests. Robert A. Rissman reports no conflicts of interests. Anne M. Fagan reports no conflicts of interests. Pankaj Oberoi and Robert Umek hold affiliations with Meso Scale Discovery and report no conflicts of interests Michael W. Weiner reports no conflicts of interests. Paula Grammas reports no conflicts of interests. Holly Posner holds affiliations with Pfizer Inc. and reports no conflicts of interests. Ralph Martins reports no conflicts of interests. Publisher Copyright: {\textcopyright} 2015 The Authors.",
year = "2015",
month = may,
day = "1",
doi = "10.1016/j.jalz.2014.08.099",
language = "English",
volume = "11",
pages = "549--560",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
number = "5",
}