Guidelines for the measurement of vascular function and structure in isolated arteries and veins

Camilla F. Wenceslau, Cameron G. McCarthy, Scott Earley, Sarah K. England, Jessica A. Filosa, Styliani Goulopoulou, David D. Gutterman, Brant E. Isakson, Nancy L. Kanagy, Luis A. Martinez-Lemus, Swapnil K. Sonkusare, Pratish Thakore, Aaron J. Trask, Stephanie W. Watts, R. Clinton Webb

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over scientific rigor and reproducibility. Therefore, it is appropriate to set guidelines for the best practices of evaluating vascular function in isolated vessels. These guidelines are a comprehensive document detailing the best practices and pitfalls for the assessment of function in large and small arteries and veins. Herein, we bring together experts in the field of vascular physiology with the purpose of developing guidelines for evaluating ex vivo vascular function. By using this document, vascular physiologists will have consistency among methodological approaches, producing more reliable and reproducible results.

Original languageEnglish
Pages (from-to)H77-H111
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number1
StatePublished - Jul 2021


  • Arteries
  • Contraction
  • Methods
  • Relaxation
  • Veins


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