TY - JOUR
T1 - Guideline-Directed Medical Therapy in Females with Heart Failure with Reduced Ejection Fraction
AU - Agarwal, Anubha
AU - Peters, Sanne A.E.
AU - Chandramouli, Chanchal
AU - Lam, Carolyn S.P.
AU - Figtree, Gemma A.
AU - Arnott, Clare
N1 - Funding Information:
Carolyn SP Lam reports grants from National Medical Research Council Singapore, non-financial support from Boston Scientific, non-financial support and other from Bayer, non-financial support from Thermofisher, non-financial support from Vifor Pharma, other from Takeda, other from Merck, other from Astra Zeneca, other from Janssen Research & Development, other from LLC, other from Menarini, other from Boehringer Ingelheim, other from Abbott Diagnostics, other from DC Devices, other from PCT/SG2016/050217 Patent pending, outside the submitted work.
Funding Information:
Chanchal Chandramouli reports grants from National Medical Research Council Singapore, philanthropic research grants from Lee Foundation Singapore other from Boehringer Ingelheim and Sanofi Aventis.
Funding Information:
Gemma A Figtree has received research support from the cofunded Australian National Health and Medical Research Council and Heart Foundation fellowship and Heart Research Australia; and has received compensation from Janssen for serving on the adjudication panel of the CANVAS Program.
Funding Information:
Clare Arnott is supported by a NSW Health Early-Mid Career Fellowship and NHMRC/MRFF Priority Investigator Grant.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/10
Y1 - 2021/10
N2 - Purpose of Review: This narrative review synthesizes sex differences in guideline-directed medical therapy (GDMT) use and response among female patients with heart failure with reduced ejection fraction (HFrEF), discusses female representation in HFrEF clinical trials, and outlines future areas of investigation to reduce sex disparities in HFrEF care globally. Recent Findings: Observational registries suggest sex-specific disparities persist in GDMT rates, and there may be key sex-specific differences in optimal dosing of GDMT in HFrEF patients. Underrepresentation of female patients in HF clinical trials is a key barrier, and sex disparities in HF clinical trial leadership may influence sex-specific knowledge generation of medical management of HFrEF patients. Summary: There are important sex-specific differences in GDMT use and response among female HFrEF patients that warrant further study. Increasing female representation in HFrEF clinical trials, diversifying HF trial leadership, and embedding sex-specific approaches in the lifecycle of research from conception to reporting are essential to decreasing sex disparities in clinical care of all HFrEF patients.
AB - Purpose of Review: This narrative review synthesizes sex differences in guideline-directed medical therapy (GDMT) use and response among female patients with heart failure with reduced ejection fraction (HFrEF), discusses female representation in HFrEF clinical trials, and outlines future areas of investigation to reduce sex disparities in HFrEF care globally. Recent Findings: Observational registries suggest sex-specific disparities persist in GDMT rates, and there may be key sex-specific differences in optimal dosing of GDMT in HFrEF patients. Underrepresentation of female patients in HF clinical trials is a key barrier, and sex disparities in HF clinical trial leadership may influence sex-specific knowledge generation of medical management of HFrEF patients. Summary: There are important sex-specific differences in GDMT use and response among female HFrEF patients that warrant further study. Increasing female representation in HFrEF clinical trials, diversifying HF trial leadership, and embedding sex-specific approaches in the lifecycle of research from conception to reporting are essential to decreasing sex disparities in clinical care of all HFrEF patients.
KW - Guideline-directed medical therapy
KW - Heart failure with reduced ejection fraction
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=85109284064&partnerID=8YFLogxK
U2 - 10.1007/s11897-021-00524-z
DO - 10.1007/s11897-021-00524-z
M3 - Review article
C2 - 34213729
AN - SCOPUS:85109284064
SN - 1546-9530
VL - 18
SP - 284
EP - 289
JO - Current Heart Failure Reports
JF - Current Heart Failure Reports
IS - 5
ER -