Guideline-Directed Medical Therapy in Females with Heart Failure with Reduced Ejection Fraction

Anubha Agarwal, Sanne A.E. Peters, Chanchal Chandramouli, Carolyn S.P. Lam, Gemma A. Figtree, Clare Arnott

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Purpose of Review: This narrative review synthesizes sex differences in guideline-directed medical therapy (GDMT) use and response among female patients with heart failure with reduced ejection fraction (HFrEF), discusses female representation in HFrEF clinical trials, and outlines future areas of investigation to reduce sex disparities in HFrEF care globally. Recent Findings: Observational registries suggest sex-specific disparities persist in GDMT rates, and there may be key sex-specific differences in optimal dosing of GDMT in HFrEF patients. Underrepresentation of female patients in HF clinical trials is a key barrier, and sex disparities in HF clinical trial leadership may influence sex-specific knowledge generation of medical management of HFrEF patients. Summary: There are important sex-specific differences in GDMT use and response among female HFrEF patients that warrant further study. Increasing female representation in HFrEF clinical trials, diversifying HF trial leadership, and embedding sex-specific approaches in the lifecycle of research from conception to reporting are essential to decreasing sex disparities in clinical care of all HFrEF patients.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalCurrent Heart Failure Reports
Volume18
Issue number5
DOIs
StatePublished - Oct 2021

Keywords

  • Guideline-directed medical therapy
  • Heart failure with reduced ejection fraction
  • Sex

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