Guidance of pioneer growth cones: Filopodial contacts and coupling revealed with an antibody to Lucifer Yellow

Paul H. Taghert, Michael J. Bastiani, Robert K. Ho, Corey S. Goodman

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

We are interested in the factors that guide individual neuronal growth cones during embryonic development. We have developed an antibody to the fluorescent dye Lucifer Yellow. We use the antibody here to examine the specific filopodial contacts and dye coupling by the first growth cones in the grasshopper embryo that navigate in an axonless environment. We have studied the distribution and apparent selective adhesion of the filopodia from these pioneering growth cones in the central nervous system and periphery. Our results suggest that selective filopodial adhesion to specific "landmark" cells may play an important role in the guidance of pioneer growth cones.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalDevelopmental Biology
Volume94
Issue number2
DOIs
StatePublished - Dec 1982
Externally publishedYes

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