TY - JOUR
T1 - Guidance of pioneer growth cones
T2 - Filopodial contacts and coupling revealed with an antibody to Lucifer Yellow
AU - Taghert, Paul H.
AU - Bastiani, Michael J.
AU - Ho, Robert K.
AU - Goodman, Corey S.
N1 - Funding Information:
We thank Susannah Chang for the I-5 monoclonal John Kuwada for careful reading of the manuscript. vided by a Muscular Dystrophy fellowship to P.H.T., to M.J.B., and grants from the NSF and McKnight C.S.G. who is a Sloan Fellow.
PY - 1982/12
Y1 - 1982/12
N2 - We are interested in the factors that guide individual neuronal growth cones during embryonic development. We have developed an antibody to the fluorescent dye Lucifer Yellow. We use the antibody here to examine the specific filopodial contacts and dye coupling by the first growth cones in the grasshopper embryo that navigate in an axonless environment. We have studied the distribution and apparent selective adhesion of the filopodia from these pioneering growth cones in the central nervous system and periphery. Our results suggest that selective filopodial adhesion to specific "landmark" cells may play an important role in the guidance of pioneer growth cones.
AB - We are interested in the factors that guide individual neuronal growth cones during embryonic development. We have developed an antibody to the fluorescent dye Lucifer Yellow. We use the antibody here to examine the specific filopodial contacts and dye coupling by the first growth cones in the grasshopper embryo that navigate in an axonless environment. We have studied the distribution and apparent selective adhesion of the filopodia from these pioneering growth cones in the central nervous system and periphery. Our results suggest that selective filopodial adhesion to specific "landmark" cells may play an important role in the guidance of pioneer growth cones.
UR - http://www.scopus.com/inward/record.url?scp=0020348441&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(82)90356-6
DO - 10.1016/0012-1606(82)90356-6
M3 - Article
C2 - 7152111
AN - SCOPUS:0020348441
SN - 0012-1606
VL - 94
SP - 391
EP - 399
JO - Developmental Biology
JF - Developmental Biology
IS - 2
ER -