Group I metabotropic glutamate receptor-mediated gene expression in striatal neurons

Li Min Mao, Guo Chi Zhang, Xian Yu Liu, Eugene E. Fibuch, John Q. Wang

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Group I mGluRs (mGluR1/5) are G-protein-coupled receptors and are abundantly expressed in most of medium spiny projection neurons in the striatum. Recent evidence demonstrates that group I mGluRs are among essential regulators for constitutive and inducible gene expression in host neurons. Upon activation, mGluR1/5 signals activate extracellular signal-regulated kinases (ERKs) which in turn phosphorylate transcription factors such as cAMP response element-binding protein (CREB) and Elk-1, and thereby facilitate immediate early gene and opioid peptide gene expression. The conventional mGluR1/5 signaling cascade (phosphoinositide hydrolysis and intracellular Ca2+ release) participates in linking mGluR1/5 to ERK. Additionally, the prominent mGluR1/5 adaptor protein Homer contributes to assemble an efficient signaling apparatus connecting mGluR1/5 to gene expression. The mGluR1/5 linkage to transcription also functions in dopamine-stimulated gene expression. Together, the mGluR1/5-mediated gene expression constitutes a transcription-dependent mechanism underlying molecular adaptations and plasticity related to the pathogenesis of various mental illnesses.

Original languageEnglish
Pages (from-to)1920-1924
Number of pages5
JournalNeurochemical Research
Volume33
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • CREB
  • Dopamine
  • Dynorphin
  • ERK
  • Fos
  • Homer
  • MAPK
  • Nucleus accumbens

Fingerprint

Dive into the research topics of 'Group I metabotropic glutamate receptor-mediated gene expression in striatal neurons'. Together they form a unique fingerprint.

Cite this