@article{72202a5f24f846f8b7e7817c04772dbe,
title = "Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis",
abstract = "Group 2 innate lymphoid cells (ILC2s) have an important role in acute allergic lung inflammation. Given their distribution and function, lung ILC2s are hypothesized to coordinate epithelial responses to the external environment; however, how barrier surveillance is linked to ILC2 activation remains unclear. Here, we demonstrate that alveolar type II cells are the main source of interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) generated in response to chitin or migratory helminths. IL-33 and TSLP synergistically induce an interferon regulatory factor 4 (IRF4)-IL-9 program in ILC2s, and autocrine IL-9 promotes rapid IL-5 and IL-13 production required for optimal epithelial responses in the conducting airways. Thus, ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organizational hierarchies in other organs.",
author = "A. Mohapatra and {Van Dyken}, {S. J.} and C. Schneider and Nussbaum, {J. C.} and Liang, {H. E.} and Locksley, {R. M.}",
note = "Funding Information: We thank J-P Girard (University de Toulouse), S Ziegler (Benaroya Research Institute), and M Steinhoff for reagents, M Donne, J Rock and Z-E Wang for technical assistance, N Flores, M Consengco, and M Li for animal care and H Chapman, J Cyster, D Erle, and M Krummel for comments on the manuscript. This work was supported by National Institutes of Health grants AI026918, AI030663, and AI119944, the Howard Hughes Medical Institute, and the Sandler Asthma Basic Research Center at the University of California, San Francisco. A Mohapatra was supported by the UCSF Medical Scientist Training Program. Funding Information: We thank J-P Girard (University de Toulouse),SZiegler (Benaroya Research Institute), andMSteinhoff for reagents,MDonne, J Rock and Z-EWang for technical assistance, N Flores,MConsengco, andMLi for animal care and H Chapman, J Cyster, D Erle, and M Krummel for comments on the manuscript. This work was supported by National Institutes of Health grants AI026918, AI030663, and AI119944, the Howard Hughes Medical Institute, and the Sandler Asthma Basic Research Center at the University of California, San Francisco. A Mohapatra was supported by the UCSF Medical Scientist Training Program.",
year = "2016",
month = jan,
day = "1",
doi = "10.1038/mi.2015.59",
language = "English",
volume = "9",
pages = "275--286",
journal = "Mucosal Immunology",
issn = "1933-0219",
number = "1",
}