Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism

Jean Patrice Baillargeon, John E. Nestler, Richard E. Ostlund, Teimuraz Apridonidze, Evanthia Diamanti-Kandarakis

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

BACKGROUND: We have shown that American women with polycystic ovary syndrome (PCOS) have decreased glucose-stimulated release of a putative mediator of insulin action, D-chiro-inositol (DCI)-containing inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI (uClDCI), which was associated with hyperinsulinemia. METHODS: DCI levels and the release of insulin and DCI-IPG during an oral glucose tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek women. RESULTS: PCOS women were heavier than controls (BMI = 28.4 versus 23.7 kg/m2, P = 0.05) with higher waist-to-hip ratios (WHR = 0.78 versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and AUCinsulin (P = 0.04). In PCOS women, incremental AUCDCI-IPG was significantly decreased by 59% (2158 versus 5276%·min, P = 0.01), even after correction for BMI and WHR. Finally, increased uClDCI (r = 0.35, P = 0.04) and decreased AUC DCI-IPG (r = 0.46, P = 0.004) were significantly associated with hyperinsulinemia in all women together, even after correction for BMI and WHR (Ps = 0.02 and 0.007), and regardless of PCOS status. CONCLUSIONS: Greek women, with or without PCOS, display increased uClDCI and decreased AUC DCI-IPG in association with higher insulin levels but independent of adiposity. Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women.

Original languageEnglish
Pages (from-to)1439-1446
Number of pages8
JournalHuman Reproduction
Volume23
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Hyperinsulinemia
  • Inositolphosphoglycans
  • Inositols
  • Insulin resistance
  • Polycystic ovary syndrome

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