TY - JOUR
T1 - Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism
AU - Baillargeon, Jean Patrice
AU - Nestler, John E.
AU - Ostlund, Richard E.
AU - Apridonidze, Teimuraz
AU - Diamanti-Kandarakis, Evanthia
N1 - Funding Information:
Funding for this work was provided by the National Institutes of Health (R01HD35 629 to J.E.N., K24HD40 237 to J.E.N., R01DK58 698 to R.E.O.) and the Fonds de Recherche en Santé du Québec (Award #3158 to J-P.B.).
PY - 2008/6
Y1 - 2008/6
N2 - BACKGROUND: We have shown that American women with polycystic ovary syndrome (PCOS) have decreased glucose-stimulated release of a putative mediator of insulin action, D-chiro-inositol (DCI)-containing inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI (uClDCI), which was associated with hyperinsulinemia. METHODS: DCI levels and the release of insulin and DCI-IPG during an oral glucose tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek women. RESULTS: PCOS women were heavier than controls (BMI = 28.4 versus 23.7 kg/m2, P = 0.05) with higher waist-to-hip ratios (WHR = 0.78 versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and AUCinsulin (P = 0.04). In PCOS women, incremental AUCDCI-IPG was significantly decreased by 59% (2158 versus 5276%·min, P = 0.01), even after correction for BMI and WHR. Finally, increased uClDCI (r = 0.35, P = 0.04) and decreased AUC DCI-IPG (r = 0.46, P = 0.004) were significantly associated with hyperinsulinemia in all women together, even after correction for BMI and WHR (Ps = 0.02 and 0.007), and regardless of PCOS status. CONCLUSIONS: Greek women, with or without PCOS, display increased uClDCI and decreased AUC DCI-IPG in association with higher insulin levels but independent of adiposity. Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women.
AB - BACKGROUND: We have shown that American women with polycystic ovary syndrome (PCOS) have decreased glucose-stimulated release of a putative mediator of insulin action, D-chiro-inositol (DCI)-containing inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI (uClDCI), which was associated with hyperinsulinemia. METHODS: DCI levels and the release of insulin and DCI-IPG during an oral glucose tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek women. RESULTS: PCOS women were heavier than controls (BMI = 28.4 versus 23.7 kg/m2, P = 0.05) with higher waist-to-hip ratios (WHR = 0.78 versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and AUCinsulin (P = 0.04). In PCOS women, incremental AUCDCI-IPG was significantly decreased by 59% (2158 versus 5276%·min, P = 0.01), even after correction for BMI and WHR. Finally, increased uClDCI (r = 0.35, P = 0.04) and decreased AUC DCI-IPG (r = 0.46, P = 0.004) were significantly associated with hyperinsulinemia in all women together, even after correction for BMI and WHR (Ps = 0.02 and 0.007), and regardless of PCOS status. CONCLUSIONS: Greek women, with or without PCOS, display increased uClDCI and decreased AUC DCI-IPG in association with higher insulin levels but independent of adiposity. Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women.
KW - Hyperinsulinemia
KW - Inositolphosphoglycans
KW - Inositols
KW - Insulin resistance
KW - Polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=44449164010&partnerID=8YFLogxK
U2 - 10.1093/humrep/den097
DO - 10.1093/humrep/den097
M3 - Article
C2 - 18375940
AN - SCOPUS:44449164010
SN - 0268-1161
VL - 23
SP - 1439
EP - 1446
JO - Human Reproduction
JF - Human Reproduction
IS - 6
ER -