TY - JOUR
T1 - Grandi Byen—supporting child growth and development through integrated, responsive parenting, nutrition and hygiene
T2 - study protocol for a randomized controlled trial
AU - Kohl, Patricia L.
AU - Gyimah, Emmanuel A.
AU - Diaz, Jenna
AU - Kuhlmann, F. Matthew
AU - Dulience, Sherlie Jean Louis
AU - Embaye, Fithi
AU - Brown, Derek S.
AU - Guo, Shenyang
AU - Luby, Joan L.
AU - Nicholas, Jennifer L.
AU - Turner, Jay
AU - Chapnick, Melissa
AU - Pierre, Joseline Marhone
AU - Boncy, Jacques
AU - St. Fleur, Rony
AU - Black, Maureen M.
AU - Iannotti, Lora L.
N1 - Funding Information:
The Principal Investigators would like to acknowledge the Institute of Public Health at Washington University in St. Louis for funding which supported the pilot study for the current Grandi Byen project. The authors are also thankful for the support of our partners based in Haiti: The Ministry of Public Health and Population in Haiti, The Fort Saint Michel Clinic, the Justinien University Hospital, and Konbit Sante. Finally, we express our gratitude to the mothers, caregivers, and children participating in the study.
Funding Information:
The Principal Investigators would like to acknowledge the Institute of Public Health at Washington University in St. Louis for funding which supported the pilot study for the current Grandi Byen project. The authors are also thankful for the support of our partners based in Haiti: The Ministry of Public Health and Population in Haiti, The Fort Saint Michel Clinic, the Justinien University Hospital, and Konbit Sante. Finally, we express our gratitude to the mothers, caregivers, and children participating in the study.
Funding Information:
This project and publication are supported by Grant Number R01HD098255-02 (L.L. Iannotti and P.L. Kohl, MPI) from the Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD). The funder has no role in the design and implementation of this study. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Poor child growth and development outcomes stem from complex relationships encompassing biological, behavioral, social, and environmental conditions. However, there is a dearth of research on integrated approaches targeting these interwoven factors. The Grandi Byen study seeks to fill this research gap through a three-arm longitudinal randomized controlled trial which will evaluate the impact of an integrated nutrition, responsive parenting, and WASH (water, sanitation and hygiene) intervention on holistic child growth and development. Methods: We will recruit 600 mother-infant dyads living in Cap-Haitien, Haiti and randomize them equally into one of the following groups: 1) standard well-baby care; 2) nutritional intervention (one egg per day for 6 months); and 3) multicomponent Grandi Byen intervention (responsive parenting, nutrition, WASH + one egg per day for 6 months). Primary outcomes include child growth as well as cognitive, language, motor, and social-emotional development. The study also assesses other indicators of child health (bone maturation, brain growth, diarrheal morbidity and allergies, dietary intake, nutrient biomarkers) along with responsive parenting as mediating factors influencing the primary outcomes. An economic evaluation will assess the feasibility of large-scale implementation of the interventions. Discussion: This study builds on research highlighting the importance of responsive parenting interventions on overall child health, as well as evidence demonstrating that providing an egg daily to infants during the complementary feeding period can prevent stunted growth. The multicomponent Grandi Byen intervention may provide evidence of synergistic or mediating effects of an egg intervention with instruction on psychoeducational parenting and WASH on child growth and development. Grandi Byen presents key innovations with implications for the well-being of children living in poverty globally. Trial registration: NCT04785352. Registered March 5, 2021 at https://clinicaltrials.gov/.
AB - Background: Poor child growth and development outcomes stem from complex relationships encompassing biological, behavioral, social, and environmental conditions. However, there is a dearth of research on integrated approaches targeting these interwoven factors. The Grandi Byen study seeks to fill this research gap through a three-arm longitudinal randomized controlled trial which will evaluate the impact of an integrated nutrition, responsive parenting, and WASH (water, sanitation and hygiene) intervention on holistic child growth and development. Methods: We will recruit 600 mother-infant dyads living in Cap-Haitien, Haiti and randomize them equally into one of the following groups: 1) standard well-baby care; 2) nutritional intervention (one egg per day for 6 months); and 3) multicomponent Grandi Byen intervention (responsive parenting, nutrition, WASH + one egg per day for 6 months). Primary outcomes include child growth as well as cognitive, language, motor, and social-emotional development. The study also assesses other indicators of child health (bone maturation, brain growth, diarrheal morbidity and allergies, dietary intake, nutrient biomarkers) along with responsive parenting as mediating factors influencing the primary outcomes. An economic evaluation will assess the feasibility of large-scale implementation of the interventions. Discussion: This study builds on research highlighting the importance of responsive parenting interventions on overall child health, as well as evidence demonstrating that providing an egg daily to infants during the complementary feeding period can prevent stunted growth. The multicomponent Grandi Byen intervention may provide evidence of synergistic or mediating effects of an egg intervention with instruction on psychoeducational parenting and WASH on child growth and development. Grandi Byen presents key innovations with implications for the well-being of children living in poverty globally. Trial registration: NCT04785352. Registered March 5, 2021 at https://clinicaltrials.gov/.
KW - Child development
KW - Integrated parenting intervention
KW - Nutrition
KW - Responsive parenting
KW - Stunting
UR - http://www.scopus.com/inward/record.url?scp=85123448451&partnerID=8YFLogxK
U2 - 10.1186/s12887-021-03089-x
DO - 10.1186/s12887-021-03089-x
M3 - Article
C2 - 35062907
AN - SCOPUS:85123448451
SN - 1471-2431
VL - 22
JO - BMC Pediatrics
JF - BMC Pediatrics
IS - 1
M1 - 54
ER -