Gq signaling in cardiac adaptation and maladaptation

Gerald W. Dorn, Joan Heller Brown

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

Accumulating evidence suggests that cardiac responses to a number of circulating or locally released humoral factors contribute to adaptive responses after hemodynamic stress or myocardial injury. In particular, hormones such as angiotensin II, endothelin 1, norepinephrine and prostaglandin F2(α) which bind to and activate cardiomyocyte membrane receptors coupled to the Gq class of GTP binding proteins have been implicated in the development and ultimate decompensation of cardiac hypertrophy. Herein we summarize recent developments in cultured cardiomyocyte and transgenic mouse systems which are defining the phenotypes resulting from Gq signaling events in cardiomyocytes, and which are elucidating the critical downstream mediators. Postulated roles for protein kinase C, p38 MAP kinase and jun-N terminal kinase are discussed in relation to Gq-mediated cardiomyocyte hypertrophy and apoptotic signaling. The evidence to date suggests that molecular targeting of Gq or its effectors has the potential to modify cardiac adaptive and maladaptive responses to stress or injury.

Original languageEnglish
Pages (from-to)26-34
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume9
Issue number1-2
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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