@article{021cb824f9c744e28ffecab3326cf6d0,
title = "Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair",
abstract = "Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe non cell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair.",
keywords = "Adhesion GPCR, Gpr126, Nerve injury, Remyelination, Schwann cell",
author = "Amit Mogha and Harty, {Breanne L.} and Dan Carlin and Jessica Joseph and Sanchez, {Nicholas E.} and Ueli Suter and Xianhua Piao and Valeria Cavalli and Monk, {Kelly R.}",
note = "Funding Information: This work was supported by National Institutes of Health (NIH) grant F31NS094004 to B.L.H., the Swiss National Science Foundation to U.S., NIH grants DE022000 and NS082446 to V.C., by a grant from the Muscular Dystrophy Association (MDA293295) to X.P. and K.R.M., and by NIH grant NS079445 to K.R.M.Wethank Peter Arthur-Farraj for valuable conversations, Aaron DiAntonio for helpful suggestions as well as the SCG10 antibody, Albina Jablonka for assistance with extensor digitorum longus muscle dissection and for providing related reagents, and Monk and Cavalli laboratory members for critical feedback and discussions. We also thank Charleen Johnson and Zachary Spence for excellent mouse care and Robyn Roth and Marilyn Levy for transmission electron microscopy assistance. The authors declare no competing financial interests. Publisher Copyright: {\textcopyright} 2016 the authors.",
year = "2016",
month = dec,
day = "7",
doi = "10.1523/JNEUROSCI.3854-15.2016",
language = "English",
volume = "36",
pages = "12351--12367",
journal = "Journal of Neuroscience",
issn = "0270-6474",
number = "49",
}