TY - JOUR
T1 - Good at heart
T2 - Preserving cardiac metabolism during aging
AU - Sorriento, Daniela
AU - Franco, Antonietta
AU - Rusciano, Maria Rosaria
AU - Maione, Angela Serena
AU - Soprano, Maria
AU - Illario, Maddalena
AU - Iaccarino, Guido
AU - Ciccarelli, Michele
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The natural process of aging determinates several cardiac modifications with increased susceptibility to heart diseases and ultimately converging on development of chronic heart failure as final stage. These changes mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity, as demonstrated in several humans and animal models of aging. While different theories have been proposed to explain the natural process of aging, it is clear that most of the alterations affect mechanisms involved in cell homeostasis and maintenance. Latest research studies have in particular focused on role of mitochondrial oxidative stress, energy production and mitochondria quality control. This article reviews the central role played by this organelle in aging and the role of new molecular players involved into the progression toward heart failure and potentially susceptible of new “anti-aging” strategies.
AB - The natural process of aging determinates several cardiac modifications with increased susceptibility to heart diseases and ultimately converging on development of chronic heart failure as final stage. These changes mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity, as demonstrated in several humans and animal models of aging. While different theories have been proposed to explain the natural process of aging, it is clear that most of the alterations affect mechanisms involved in cell homeostasis and maintenance. Latest research studies have in particular focused on role of mitochondrial oxidative stress, energy production and mitochondria quality control. This article reviews the central role played by this organelle in aging and the role of new molecular players involved into the progression toward heart failure and potentially susceptible of new “anti-aging” strategies.
KW - Aging
KW - Heart failure
KW - Insulin resistance
KW - Metabolism
KW - Mitochondria
KW - Mitophagy
KW - Neurohormonal activation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84959498822&partnerID=8YFLogxK
U2 - 10.2174/1573399811666150722124958
DO - 10.2174/1573399811666150722124958
M3 - Article
C2 - 26201429
AN - SCOPUS:84959498822
SN - 1573-3998
VL - 12
SP - 90
EP - 99
JO - Current Diabetes Reviews
JF - Current Diabetes Reviews
IS - 2
ER -