Gold Nanoparticles Doped with 199Au Atoms and Their Use for Targeted Cancer Imaging by SPECT

Yongfeng Zhao, Bo Pang, Hannah Luehmann, Lisa Detering, Xuan Yang, Deborah Sultan, Scott Harpstrite, Vijay Sharma, Cathy S. Cutler, Younan Xia, Yongjian Liu

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Gold nanoparticles have been labeled with various radionuclides and extensively explored for single photon emission computed tomography (SPECT) in the context of cancer diagnosis. The stability of most radiolabels, however, still needs to be improved for accurate detection of cancer biomarkers and thereby monitoring of tumor progression and metastasis. Here, the first synthesis of Au nanoparticles doped with 199Au atoms for targeted SPECT tumor imaging in a mouse triple negative breast cancer (TNBC) model is reported. By directly incorporating 199Au atoms into the crystal lattice of each Au nanoparticle, the stability of the radiolabel can be ensured. The synthetic procedure also allows for a precise control over both the radiochemistry and particle size. When conjugated with D-Ala1-peptide T-amide, the Au nanoparticles doped with 199Au atoms can serve as a C-C chemokine receptor 5 (CCR5)-targeted nanoprobe for the sensitive and specific detection of both TNBC and its metastasis in a mouse tumor model. Radioactive Au nanoparticles doped with 199Au atoms are conjugated with D-Ala1-peptide T-amide to serve as a CCR5-targeted nanoprobe for the sensitive and specific detection of both triple negative breast cancer and its metastasis in a mouse model by single photon emission computed tomography (SPECT).

Original languageEnglish
Pages (from-to)928-935
Number of pages8
JournalAdvanced Healthcare Materials
Volume5
Issue number8
DOIs
StatePublished - Apr 20 2016

Keywords

  • Breast cancer
  • CCR5 targeting
  • Gold nanoparticles
  • Radiolabeling
  • Single photon emission computed tomography

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