Going viral: Next-generation sequencing applied to phage populations in the human gut

Alejandro Reyes, Nicholas P. Semenkovich, Katrine Whiteson, Forest Rohwer, Jeffrey I. Gordon

Research output: Contribution to journalReview article

210 Scopus citations

Abstract

Over the past decade, researchers have begun to characterize viral diversity using metagenomic methods. These studies have shown that viruses, the majority of which infect bacteria, are probably the most genetically diverse components of the biosphere. Here, we briefly review the incipient rise of a phage biology renaissance, which has been catalysed by advances in next-generation sequencing. We explore how work characterizing phage diversity and lifestyles in the human gut is changing our view of ourselves as supra-organisms. Finally, we discuss how a renewed appreciation of phage dynamics may yield new applications for phage therapies designed to manipulate the structure and functions of our gut microbiomes.

Original languageEnglish
Pages (from-to)607-617
Number of pages11
JournalNature Reviews Microbiology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2012

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