TY - JOUR
T1 - Going viral
T2 - A novel role for bacteriophage in colorectal cancer
AU - Handley, Scott A.
AU - Devkota, Suzanne
N1 - Publisher Copyright:
© 2019 Handley and Devkota.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the mi-crobiome, which have emerged with identifiable disease signatures in other dis-eases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.
AB - Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the mi-crobiome, which have emerged with identifiable disease signatures in other dis-eases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.
KW - Bacteriophage
KW - Colorectal cancer
KW - Microbiome
KW - Virome
UR - http://www.scopus.com/inward/record.url?scp=85060401815&partnerID=8YFLogxK
U2 - 10.1128/mBio.02626-18
DO - 10.1128/mBio.02626-18
M3 - Article
C2 - 30670618
AN - SCOPUS:85060401815
VL - 10
JO - mBio
JF - mBio
SN - 2161-2129
IS - 1
M1 - e02626-18
ER -