Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

Yukitoshi Izumi; David B. Clifford; Charles F. Zorumski

doi:10.1016/0304-3940(90)90212-R

Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

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Abstract

The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Neuroscience Letters
Volume	112
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(90)90212-R
State	Published - May 4 1990

Keywords

7-Chlorokynurenic acid
Cycloleucine
Glycine
Hippocampus
Long-term potentiation
N-Methyl-d-aspartate

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10.1016/0304-3940(90)90212-R

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@article{0e8c6d269c96437fb86d64b66e215d00,

title = "Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices",

abstract = "The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.",

keywords = "7-Chlorokynurenic acid, Cycloleucine, Glycine, Hippocampus, Long-term potentiation, N-Methyl-d-aspartate",

author = "Yukitoshi Izumi and Clifford, \{David B.\} and Zorumski, \{Charles F.\}",

note = "Funding Information: This work was supported in part by NIMH Physician Scientist Award MH00630, the Klingenstein Foundation and Grants AG05681 and DA05072. The authors thank Drs. Gary D. Clark, Jay Yang and Liu Lin Thio for helpful comments and suggestions.",

year = "1990",

month = may,

day = "4",

doi = "10.1016/0304-3940(90)90212-R",

language = "English",

volume = "112",

pages = "251--256",

journal = "Neuroscience Letters",

issn = "0304-3940",

number = "2-3",

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TY - JOUR

T1 - Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

AU - Izumi, Yukitoshi

AU - Clifford, David B.

AU - Zorumski, Charles F.

N1 - Funding Information: This work was supported in part by NIMH Physician Scientist Award MH00630, the Klingenstein Foundation and Grants AG05681 and DA05072. The authors thank Drs. Gary D. Clark, Jay Yang and Liu Lin Thio for helpful comments and suggestions.

PY - 1990/5/4

Y1 - 1990/5/4

N2 - The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.

AB - The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.

KW - 7-Chlorokynurenic acid

KW - Cycloleucine

KW - Glycine

KW - Hippocampus

KW - Long-term potentiation

KW - N-Methyl-d-aspartate

UR - https://www.scopus.com/pages/publications/0025699764

U2 - 10.1016/0304-3940(90)90212-R

DO - 10.1016/0304-3940(90)90212-R

M3 - Article

C2 - 2359524

AN - SCOPUS:0025699764

SN - 0304-3940

VL - 112

SP - 251

EP - 256

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2-3

ER -

Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

Abstract

Keywords

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