Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

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Abstract

The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalNeuroscience Letters
Volume112
Issue number2-3
DOIs
StatePublished - May 4 1990

Keywords

  • 7-Chlorokynurenic acid
  • Cycloleucine
  • Glycine
  • Hippocampus
  • Long-term potentiation
  • N-Methyl-d-aspartate

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