TY - JOUR
T1 - Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices
AU - Izumi, Yukitoshi
AU - Clifford, David B.
AU - Zorumski, Charles F.
N1 - Funding Information:
This work was supported in part by NIMH Physician Scientist Award MH00630, the Klingenstein Foundation and Grants AG05681 and DA05072. The authors thank Drs. Gary D. Clark, Jay Yang and Liu Lin Thio for helpful comments and suggestions.
PY - 1990/5/4
Y1 - 1990/5/4
N2 - The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.
AB - The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.
KW - 7-Chlorokynurenic acid
KW - Cycloleucine
KW - Glycine
KW - Hippocampus
KW - Long-term potentiation
KW - N-Methyl-d-aspartate
UR - http://www.scopus.com/inward/record.url?scp=0025699764&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(90)90212-R
DO - 10.1016/0304-3940(90)90212-R
M3 - Article
C2 - 2359524
AN - SCOPUS:0025699764
SN - 0304-3940
VL - 112
SP - 251
EP - 256
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -