Glycemic impact of a diet and lifestyle intervention on diabetics and prediabetics during treatment for non-muscle invasive bladder cancer

Connor Chestnut, Woodson Smelser, Travis Dum, Misty Bechtel, Lauren Hand, Carrie Michel, Areej Bawajeeh, Sepideh Zohreh, Weiya Liu, Shrikant Anant, David Robbins, Jeffrey M. Holzbeierlein, Jill Hamilton-Reeves, Eugene K. Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: Patients with Type II Diabetes Mellitus (DM2) have increased risk of recurrence and progression of non-muscle invasive bladder cancer (NMIBC). Glucose control through lifestyle intervention is an uninvestigated, attractive strategy to decrease risk of cancer recurrence. We test the feasibility of a diet and exercise program and its glycemic impact in patients with DM2 and NMIBC. Materials/methods: Five participants with NMIBC and pre-diabetes or DM2 were recruited for a pilot, prospective clinical trial. Each participant received dietary counseling for 16 sessions during clinical visits. The intervention included a carbohydrate-restricted (CR) diet (<130 grams per day), 30 min, walking 5×/wk, and 5000 steps daily. Diet compliance was measured with 24-hour diet recall. Exercise was monitored with accelerometer and self-report. Results: Five participants enrolled and two participants completed the 12-month intervention. Adherence was 60% to CR diet and 84% to exercise goals. Participants reduced carbohydrate consumption by 44%. Participants showed reductions in fasting blood glucose, HbA1c, glucosuria, fasting blood insulin, and body weight, and increased euglycemia on continuous glucose monitoring. Conclusions: Adherence to a CR diet and exercise goals is feasible in patients with NMIBC and DM2 and also leads improved glucose control. A phase-II trial on bladder cancer-specific outcomes is warranted.

Original languageEnglish
Pages (from-to)1219-1224
Number of pages6
JournalNutrition and Cancer
Volume72
Issue number7
DOIs
StatePublished - Oct 2 2020

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