Glutathione plays a role in the chick intestinal calcium absorption

Nori Tolosa De Talamoni, A. Marchionatti, V. Baudino, A. Alisio

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

DL-buthionine-S,R-sulfoximine (BSO) administration to vitamin D-deficient chicks treated with cholecalciferol produces a rapid decrease in the Ca2+ transfer from lumen-to-plasma and in the intestinal glutathione content. This response was reversed by addition of glutathione monoester to the intestinal sac. Variables related to the Ca2+ homeostasis such as plasma Ca and P, and intestinal calbindin D(28k) were not modified by BSO given to vitamin D-deficient chicks treated with cholecalciferol. Intestinal alkaline phosphatase activity, on the contrary, was highly reduced by BSO in vitamin D-deficient chicks treated with vitamin D3. This effect showed time and dose-dependency. Although the mechanism/s of action of BSO on the intestinal Ca absorption is unknown, it is quite possible that thiol groups of proteins involved in the Ca2+ transport are affected by the GSH depletion and/or by block of the antioxidant ability of vitamin D3. Thus, reactive oxygen compounds would be increased and, therefore, the Ca2+ movement from lumen to plasma decreases.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalComparative Biochemistry and Physiology - A Physiology
Volume115
Issue number2
DOIs
StatePublished - Oct 1996

Keywords

  • alkaline phosphatase
  • basolateral membrane
  • Ca transfer from lumen-to-blood
  • Ca uptake
  • chicks
  • cholecalciferol
  • DL-buthionine-S,R-sulfoximine
  • glutathion e
  • intestine

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