Glutamatergic Transmission in the Medial Vestibular Nucleus

N. T. Slater, L. N. Eisenman, G. A. Kinney, B. W. Peterson, J. C. Houk

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter reviews the available data concerning the pharmacological and biophysical properties of transmission, which incorporated in a model that relates these features to the performance of the primary afferent second order neuron pathway during vestibular stimulation. A considerable body of evidence now exists demonstrating that transmission at synapses between vestibular primary afferents and second-order neurons of the medial vestibular nucleus (MVN) is glutamatergic in nature. The existence of recurrent excitatory collaterals between MVN neurons that are modulated by GABAergic inhibition is supported by extracellular single-unit studies of the tonic firing rate of MVN neurons in vitro, which is enhanced by GABAA receptor antagonists. Patch-clamp studies of glutamate receptor-mediated currents have provided a detailed picture of the behavior of the NMDA receptor-channel complex to be utilized in the construction of a kinetic model of the NMDA receptor-mediated EPSC in MVN neurons.

Original languageEnglish
Title of host publicationNeurochemistry of the Vestibular System
PublisherCRC Press
Number of pages16
ISBN (Electronic)9781351428903
ISBN (Print)9780849376795
StatePublished - Jan 1 2023


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