Glutamatergic Transmission in the Medial Vestibular Nucleus

N. T. Slater; L. N. Eisenman; G. A. Kinney; B. W. Peterson; J. C. Houk

doi:10.1201/9780203745922-9

Glutamatergic Transmission in the Medial Vestibular Nucleus

N. T. Slater, L. N. Eisenman, G. A. Kinney, B. W. Peterson, J. C. Houk

Section of Adult Epilepsy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter reviews the available data concerning the pharmacological and biophysical properties of transmission, which incorporated in a model that relates these features to the performance of the primary afferent second order neuron pathway during vestibular stimulation. A considerable body of evidence now exists demonstrating that transmission at synapses between vestibular primary afferents and second-order neurons of the medial vestibular nucleus (MVN) is glutamatergic in nature. The existence of recurrent excitatory collaterals between MVN neurons that are modulated by GABAergic inhibition is supported by extracellular single-unit studies of the tonic firing rate of MVN neurons in vitro, which is enhanced by GABAA receptor antagonists. Patch-clamp studies of glutamate receptor-mediated currents have provided a detailed picture of the behavior of the NMDA receptor-channel complex to be utilized in the construction of a kinetic model of the NMDA receptor-mediated EPSC in MVN neurons.

Original language	English
Title of host publication	Neurochemistry of the Vestibular System
Publisher	CRC Press
Pages	127-142
Number of pages	16
ISBN (Electronic)	9781351428903
ISBN (Print)	9780849376795
DOIs	https://doi.org/10.1201/9780203745922-9
State	Published - Jan 1 2023

Access to Document

10.1201/9780203745922-9

Cite this

@inbook{3562b9cee8c24177b9502a8c963dd050,

title = "Glutamatergic Transmission in the Medial Vestibular Nucleus",

abstract = "This chapter reviews the available data concerning the pharmacological and biophysical properties of transmission, which incorporated in a model that relates these features to the performance of the primary afferent second order neuron pathway during vestibular stimulation. A considerable body of evidence now exists demonstrating that transmission at synapses between vestibular primary afferents and second-order neurons of the medial vestibular nucleus (MVN) is glutamatergic in nature. The existence of recurrent excitatory collaterals between MVN neurons that are modulated by GABAergic inhibition is supported by extracellular single-unit studies of the tonic firing rate of MVN neurons in vitro, which is enhanced by GABAA receptor antagonists. Patch-clamp studies of glutamate receptor-mediated currents have provided a detailed picture of the behavior of the NMDA receptor-channel complex to be utilized in the construction of a kinetic model of the NMDA receptor-mediated EPSC in MVN neurons.",

author = "Slater, {N. T.} and Eisenman, {L. N.} and Kinney, {G. A.} and Peterson, {B. W.} and Houk, {J. C.}",

note = "Publisher Copyright: {\textcopyright} 2000 by Taylor & Francis Group, LLC.",

year = "2023",

month = jan,

day = "1",

doi = "10.1201/9780203745922-9",

language = "English",

isbn = "9780849376795",

pages = "127--142",

booktitle = "Neurochemistry of the Vestibular System",

publisher = "CRC Press",

}

TY - CHAP

T1 - Glutamatergic Transmission in the Medial Vestibular Nucleus

AU - Slater, N. T.

AU - Eisenman, L. N.

AU - Kinney, G. A.

AU - Peterson, B. W.

AU - Houk, J. C.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - This chapter reviews the available data concerning the pharmacological and biophysical properties of transmission, which incorporated in a model that relates these features to the performance of the primary afferent second order neuron pathway during vestibular stimulation. A considerable body of evidence now exists demonstrating that transmission at synapses between vestibular primary afferents and second-order neurons of the medial vestibular nucleus (MVN) is glutamatergic in nature. The existence of recurrent excitatory collaterals between MVN neurons that are modulated by GABAergic inhibition is supported by extracellular single-unit studies of the tonic firing rate of MVN neurons in vitro, which is enhanced by GABAA receptor antagonists. Patch-clamp studies of glutamate receptor-mediated currents have provided a detailed picture of the behavior of the NMDA receptor-channel complex to be utilized in the construction of a kinetic model of the NMDA receptor-mediated EPSC in MVN neurons.

AB - This chapter reviews the available data concerning the pharmacological and biophysical properties of transmission, which incorporated in a model that relates these features to the performance of the primary afferent second order neuron pathway during vestibular stimulation. A considerable body of evidence now exists demonstrating that transmission at synapses between vestibular primary afferents and second-order neurons of the medial vestibular nucleus (MVN) is glutamatergic in nature. The existence of recurrent excitatory collaterals between MVN neurons that are modulated by GABAergic inhibition is supported by extracellular single-unit studies of the tonic firing rate of MVN neurons in vitro, which is enhanced by GABAA receptor antagonists. Patch-clamp studies of glutamate receptor-mediated currents have provided a detailed picture of the behavior of the NMDA receptor-channel complex to be utilized in the construction of a kinetic model of the NMDA receptor-mediated EPSC in MVN neurons.

UR - http://www.scopus.com/inward/record.url?scp=85165381070&partnerID=8YFLogxK

U2 - 10.1201/9780203745922-9

DO - 10.1201/9780203745922-9

M3 - Chapter

AN - SCOPUS:85165381070

SN - 9780849376795

SP - 127

EP - 142

BT - Neurochemistry of the Vestibular System

PB - CRC Press

ER -

Glutamatergic Transmission in the Medial Vestibular Nucleus

Abstract

Access to Document

Other files and links

Fingerprint

Cite this