Glutamate modulates neurotransmission in the submucosal plexus of guinea-pig small intestine

Jun Ren, Hong Zhen Hu, Sumei Liu, Yun Xia, Jackie D. Wood

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Effects of glutamate on synaptic transmission in the submucosal plexus of guinea-pig small intestine were studied with intracellular electrophysiological recording methods. Glutamate suppressed stimulus-evoked slow excitatory postsynaptic potentials (EPSPs) and increased the amplitude of slow inhibitory postsynaptic potentials (IPSPs) in submucosal neurons. The actions of glutamate were mimicked by the group I metabotropic glutamate receptor (mGluRs) agonist DHPG, but not by the group II agonist S-4C3HPG, the group III agonist L-AP4, or selective agonists for ionotropic glutamate receptors (iGluRs). Glutamate actions were suppressed by the selective group I mGluRs antagonist S-4CPG, but not by group II and III mGluRs antagonist CPPG or iGluRs antagonists. Glutamate suppressed substance P- and 5-HT-evoked slow EPSP-like responses and potentiated norepinephrine-induced slow IPSP- like responses. The results suggest that group I mGluRs mediate glutamate- induced suppression of slow EPSPs and potentiation of slow IPSPs in S-type uniaxonal submucosal neurons.

Original languageEnglish
Pages (from-to)3045-3048
Number of pages4
JournalNeuroReport
Volume10
Issue number14
DOIs
StatePublished - Sep 29 1999

Keywords

  • Enteric nervous system
  • Ionotropic glutamate receptor
  • Metabotropic glutamate receptor
  • Small intestine
  • Submucosal plexus

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