Glutamate and the presynaptic control of spinal sensory transmission

James E. Huettner, Geoffrey A. Kerchner, Min Zhuo

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


Sensory neurons, in particular the small- and medium-diameter cells that sense painful stimuli, express both ionotropic and metabotropic glutamate receptors, which may regulate transmission between sensory neurons and their targets in the spinal cord dorsal horn. Although the roles that these receptors play in normal physiology are not completely understood, recent work has provided strong evidence for their ability to modulate transmitter release from primary afferent terminals.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
Issue number2
StatePublished - 2002


  • Dorsal root ganglia
  • Pain
  • Transmitter release


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