GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst

Mary O. Carayannopoulos, Maggie M.Y. Chi, Ying Cui, Joyce M. Pingsterhaus, Robert A. McKnight, Mike Mueckler, Sherin U. Devaskar, Kelle H. Moley

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Abstract

Mammalian preimplantation blastocysts exhibit insulin-stimulated glucose uptake despite the absence of the only known insulin-regulated transporter, GLUT4. We describe a previously unidentified member of the mammalian facilitative GLUT superfamily that exhibits ≃20-25% identity with other murine facilitative GLUTs. Insulin induces a change in the intracellular localization of this protein, which translates into increased glucose uptake into the blastocyst, a process that is inhibited by antisense oligoprobes. Presence of this transporter may be necessary for successful blastocyst development, fuel metabolism, and subsequent implantation. Moreover, the existence of an alternative transporter may explain examples in other tissues of insulin-regulated glucose transport in the absence of GLUT4.

Original languageEnglish
Pages (from-to)7313-7318
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number13
DOIs
StatePublished - Jun 20 2000

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    Carayannopoulos, M. O., Chi, M. M. Y., Cui, Y., Pingsterhaus, J. M., McKnight, R. A., Mueckler, M., Devaskar, S. U., & Moley, K. H. (2000). GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7313-7318. https://doi.org/10.1073/pnas.97.13.7313