Glucose transporters in the intervertebral disc

Ali Mobasheri, Carolyn A. Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen M. Richardson, Judith A. Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry and cell biology, but morphologically it is clearly different (Roberts 2002; Urban and Roberts 2003). The disc shows degenerative and ageing changes earlier than any other connective tissue in the human body (Urban and Roberts 2003). The maintenance of the ECM in the NP of the adult human disc is dependent on the functional integrity of the cartilage end plate cells (Pritzker 1977). Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. It has been proposed that intervertebral disc narrowing and collapse are related to metabolic failure of matrix production by end plate and annulus fibrosus cells (Pritzker 1977).

Original languageEnglish
Title of host publicationFacilitative Glucose Transporters in Articular Chondrocytes
Subtitle of host publicationExpression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok
EditorsAli Mobasheri, Carolyn Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen Richardson, Judith Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei
Number of pages5
StatePublished - 2008

Publication series

NameAdvances in Anatomy Embryology and Cell Biology
ISSN (Print)0301-5556


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