Glucose transporters in the intervertebral disc

Ali Mobasheri; Carolyn A. Bondy; Kelle Moley; Alexandrina Ferreira Mendes; Susana Carvalho Rosa; Stephen M. Richardson; Judith A. Hoyland; Richard Barrett-Jolley; Mehdi Shakibaei

doi:10.1007/978-3-540-78899-7_9

Glucose transporters in the intervertebral disc

Ali Mobasheri, Carolyn A. Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen M. Richardson, Judith A. Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei

Department of Obstetrics & Gynecology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry and cell biology, but morphologically it is clearly different (Roberts 2002; Urban and Roberts 2003). The disc shows degenerative and ageing changes earlier than any other connective tissue in the human body (Urban and Roberts 2003). The maintenance of the ECM in the NP of the adult human disc is dependent on the functional integrity of the cartilage end plate cells (Pritzker 1977). Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. It has been proposed that intervertebral disc narrowing and collapse are related to metabolic failure of matrix production by end plate and annulus fibrosus cells (Pritzker 1977).

Original language	English
Title of host publication	Facilitative Glucose Transporters in Articular Chondrocytes
Subtitle of host publication	Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok
Editors	Ali Mobasheri, Carolyn Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen Richardson, Judith Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei
Pages	53-57
Number of pages	5
DOIs	https://doi.org/10.1007/978-3-540-78899-7_9
State	Published - 2008

Publication series

Name	Advances in Anatomy Embryology and Cell Biology
Volume	200
ISSN (Print)	0301-5556

Access to Document

10.1007/978-3-540-78899-7_9

Cite this

Mobasheri, A., Bondy, C. A., Moley, K., Mendes, A. F., Rosa, S. C., Richardson, S. M., Hoyland, J. A., Barrett-Jolley, R., & Shakibaei, M. (2008). Glucose transporters in the intervertebral disc. In A. Mobasheri, C. Bondy, K. Moley, A. Ferreira Mendes, S. Carvalho Rosa, S. Richardson, J. Hoyland, R. Barrett-Jolley, & M. Shakibaei (Eds.), Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok (pp. 53-57). (Advances in Anatomy Embryology and Cell Biology; Vol. 200). https://doi.org/10.1007/978-3-540-78899-7_9

Mobasheri, Ali ; Bondy, Carolyn A. ; Moley, Kelle et al. / Glucose transporters in the intervertebral disc. Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. editor / Ali Mobasheri ; Carolyn Bondy ; Kelle Moley ; Alexandrina Ferreira Mendes ; Susana Carvalho Rosa ; Stephen Richardson ; Judith Hoyland ; Richard Barrett-Jolley ; Mehdi Shakibaei. 2008. pp. 53-57 (Advances in Anatomy Embryology and Cell Biology).

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title = "Glucose transporters in the intervertebral disc",

abstract = "The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry and cell biology, but morphologically it is clearly different (Roberts 2002; Urban and Roberts 2003). The disc shows degenerative and ageing changes earlier than any other connective tissue in the human body (Urban and Roberts 2003). The maintenance of the ECM in the NP of the adult human disc is dependent on the functional integrity of the cartilage end plate cells (Pritzker 1977). Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. It has been proposed that intervertebral disc narrowing and collapse are related to metabolic failure of matrix production by end plate and annulus fibrosus cells (Pritzker 1977).",

author = "Ali Mobasheri and Bondy, {Carolyn A.} and Kelle Moley and Mendes, {Alexandrina Ferreira} and Rosa, {Susana Carvalho} and Richardson, {Stephen M.} and Hoyland, {Judith A.} and Richard Barrett-Jolley and Mehdi Shakibaei",

year = "2008",

doi = "10.1007/978-3-540-78899-7_9",

language = "English",

isbn = "9783540788980",

series = "Advances in Anatomy Embryology and Cell Biology",

pages = "53--57",

editor = "Ali Mobasheri and Carolyn Bondy and Kelle Moley and {Ferreira Mendes}, Alexandrina and {Carvalho Rosa}, Susana and Stephen Richardson and Judith Hoyland and Richard Barrett-Jolley and Mehdi Shakibaei",

booktitle = "Facilitative Glucose Transporters in Articular Chondrocytes",

}

Mobasheri, A, Bondy, CA, Moley, K, Mendes, AF, Rosa, SC, Richardson, SM, Hoyland, JA, Barrett-Jolley, R & Shakibaei, M 2008, Glucose transporters in the intervertebral disc. in A Mobasheri, C Bondy, K Moley, A Ferreira Mendes, S Carvalho Rosa, S Richardson, J Hoyland, R Barrett-Jolley & M Shakibaei (eds), Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. Advances in Anatomy Embryology and Cell Biology, vol. 200, pp. 53-57. https://doi.org/10.1007/978-3-540-78899-7_9

Glucose transporters in the intervertebral disc. / Mobasheri, Ali; Bondy, Carolyn A.; Moley, Kelle et al.

Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. ed. / Ali Mobasheri; Carolyn Bondy; Kelle Moley; Alexandrina Ferreira Mendes; Susana Carvalho Rosa; Stephen Richardson; Judith Hoyland; Richard Barrett-Jolley; Mehdi Shakibaei. 2008. p. 53-57 (Advances in Anatomy Embryology and Cell Biology; Vol. 200).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Glucose transporters in the intervertebral disc

AU - Mobasheri, Ali

AU - Bondy, Carolyn A.

AU - Moley, Kelle

AU - Mendes, Alexandrina Ferreira

AU - Rosa, Susana Carvalho

AU - Richardson, Stephen M.

AU - Hoyland, Judith A.

AU - Barrett-Jolley, Richard

AU - Shakibaei, Mehdi

PY - 2008

Y1 - 2008

N2 - The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry and cell biology, but morphologically it is clearly different (Roberts 2002; Urban and Roberts 2003). The disc shows degenerative and ageing changes earlier than any other connective tissue in the human body (Urban and Roberts 2003). The maintenance of the ECM in the NP of the adult human disc is dependent on the functional integrity of the cartilage end plate cells (Pritzker 1977). Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. It has been proposed that intervertebral disc narrowing and collapse are related to metabolic failure of matrix production by end plate and annulus fibrosus cells (Pritzker 1977).

AB - The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry and cell biology, but morphologically it is clearly different (Roberts 2002; Urban and Roberts 2003). The disc shows degenerative and ageing changes earlier than any other connective tissue in the human body (Urban and Roberts 2003). The maintenance of the ECM in the NP of the adult human disc is dependent on the functional integrity of the cartilage end plate cells (Pritzker 1977). Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. It has been proposed that intervertebral disc narrowing and collapse are related to metabolic failure of matrix production by end plate and annulus fibrosus cells (Pritzker 1977).

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AN - SCOPUS:51049093215

SN - 9783540788980

T3 - Advances in Anatomy Embryology and Cell Biology

SP - 53

EP - 57

BT - Facilitative Glucose Transporters in Articular Chondrocytes

A2 - Mobasheri, Ali

A2 - Bondy, Carolyn

A2 - Moley, Kelle

A2 - Ferreira Mendes, Alexandrina

A2 - Carvalho Rosa, Susana

A2 - Richardson, Stephen

A2 - Hoyland, Judith

A2 - Barrett-Jolley, Richard

A2 - Shakibaei, Mehdi

ER -

Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson SM et al. Glucose transporters in the intervertebral disc. In Mobasheri A, Bondy C, Moley K, Ferreira Mendes A, Carvalho Rosa S, Richardson S, Hoyland J, Barrett-Jolley R, Shakibaei M, editors, Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. 2008. p. 53-57. (Advances in Anatomy Embryology and Cell Biology). doi: 10.1007/978-3-540-78899-7_9

Glucose transporters in the intervertebral disc

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