Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis

Brian J. DeBosch, Zhouji Chen, Jessica L. Saben, Brian N. Finck, Kelle H. Moley

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Background: GLUT8 is a facilitative fructose and glucose transporter expressed in liver. Results: GLUT8-deficient mice are resistant to fructose-induced fatty liver disease. Conclusion: Hexose transporters can mediate fructose-induced fatty liver disease. Significance: Hepatic hexose transporters represent a novel class of targets to prevent or modulate non-alcoholic fatty liver disease.

Original languageEnglish
Pages (from-to)10989-10998
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

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