Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis

Brian J. DeBosch; Zhouji Chen; Jessica L. Saben; Brian N. Finck; Kelle H. Moley

doi:10.1074/jbc.M113.527002

Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis

Brian J. DeBosch, Zhouji Chen, Jessica L. Saben, Brian N. Finck, Kelle H. Moley

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Background: GLUT8 is a facilitative fructose and glucose transporter expressed in liver. Results: GLUT8-deficient mice are resistant to fructose-induced fatty liver disease. Conclusion: Hexose transporters can mediate fructose-induced fatty liver disease. Significance: Hepatic hexose transporters represent a novel class of targets to prevent or modulate non-alcoholic fatty liver disease.

Original language	English
Pages (from-to)	10989-10998
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.527002
State	Published - Apr 18 2014

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title = "Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis",

abstract = "Background: GLUT8 is a facilitative fructose and glucose transporter expressed in liver. Results: GLUT8-deficient mice are resistant to fructose-induced fatty liver disease. Conclusion: Hexose transporters can mediate fructose-induced fatty liver disease. Significance: Hepatic hexose transporters represent a novel class of targets to prevent or modulate non-alcoholic fatty liver disease.",

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AU - DeBosch, Brian J.

AU - Chen, Zhouji

AU - Saben, Jessica L.

AU - Finck, Brian N.

AU - Moley, Kelle H.

PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: GLUT8 is a facilitative fructose and glucose transporter expressed in liver. Results: GLUT8-deficient mice are resistant to fructose-induced fatty liver disease. Conclusion: Hexose transporters can mediate fructose-induced fatty liver disease. Significance: Hepatic hexose transporters represent a novel class of targets to prevent or modulate non-alcoholic fatty liver disease.

AB - Background: GLUT8 is a facilitative fructose and glucose transporter expressed in liver. Results: GLUT8-deficient mice are resistant to fructose-induced fatty liver disease. Conclusion: Hexose transporters can mediate fructose-induced fatty liver disease. Significance: Hepatic hexose transporters represent a novel class of targets to prevent or modulate non-alcoholic fatty liver disease.

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Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis

Abstract

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