Glucagon and hyperglycaemia in diabetes

Research output: Contribution to journalComment/debate

18 Scopus citations

Abstract

Glucagon, in the setting of absolute or relative insulin deficiency, is thought to contribute to the pathogenesis of hyperglycaemia in diabetes, but much of the evidence is extrapolated from short-term studies to the long-term condition. In the present issue of Clinical Science, Li and co-workers report that infusion of glucagon raised fasting plasma glucose concentrations and impaired glucose tolerance over 4 weeks in mice, thus demonstrating a sustained glycaemic effect of hyperglucagonaemia. Nonetheless, compelling evidence that glucagon contributes to the pathogenesis of hyperglycaemia in diabetes awaits long-term selective reduction of glucagon secretion or action in humans.

Original languageEnglish
Pages (from-to)589-590
Number of pages2
JournalClinical Science
Volume114
Issue number9-10
DOIs
StatePublished - May 2008

Keywords

  • Glucagon
  • Glucose tolerance
  • Insulin deficiency
  • Kidney
  • Microalbuminuria
  • Type 2 diabetes

Fingerprint Dive into the research topics of 'Glucagon and hyperglycaemia in diabetes'. Together they form a unique fingerprint.

Cite this