TY - JOUR
T1 - Glomerular filtration
T2 - The charge debate charges ahead
AU - Miner, Jeffrey H.
N1 - Funding Information:
I thank Scott Harvey for helpful suggestions. My research is supported by grants from the National Institutes of Health, by Washington University's George M. O’Brien Kidney Research Center (NIH P30 DK079333), and by an American Heart Association Established Investigator Award.
PY - 2008/8
Y1 - 2008/8
N2 - The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
AB - The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
UR - http://www.scopus.com/inward/record.url?scp=47349130832&partnerID=8YFLogxK
U2 - 10.1038/ki.2008.260
DO - 10.1038/ki.2008.260
M3 - Comment/debate
C2 - 18626493
AN - SCOPUS:47349130832
VL - 74
SP - 259
EP - 261
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 3
ER -