TY - JOUR
T1 - Glomerular filtration
T2 - The charge debate charges ahead
AU - Miner, Jeffrey H.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2008/8
Y1 - 2008/8
N2 - The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
AB - The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
UR - http://www.scopus.com/inward/record.url?scp=47349130832&partnerID=8YFLogxK
U2 - 10.1038/ki.2008.260
DO - 10.1038/ki.2008.260
M3 - Comment/debate
C2 - 18626493
AN - SCOPUS:47349130832
VL - 74
SP - 259
EP - 261
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 3
ER -