Glomerular filtration: The charge debate charges ahead

Jeffrey H. Miner

doi:10.1038/ki.2008.260

Glomerular filtration: The charge debate charges ahead

Jeffrey H. Miner

Research output: Contribution to journal › Comment/debate

20 Scopus citations

Abstract

The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.

Original language	English
Pages (from-to)	259-261
Number of pages	3
Journal	Kidney International
Volume	74
Issue number	3
DOIs	https://doi.org/10.1038/ki.2008.260
State	Published - Aug 2008

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abstract = "The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.",

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AB - The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.

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