Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)

D. H. Gutmann; S. A. Rasmussen; P. Wolkenstein; M. M. MacCollin; A. Guha; P. D. Inskip; K. N. North; M. Poyhonen; P. H. Birch; J. M. Friedman

doi:10.1212/WNL.59.5.759

Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)

D. H. Gutmann, S. A. Rasmussen, P. Wolkenstein, M. M. MacCollin, A. Guha, P. D. Inskip, K. N. North, M. Poyhonen, P. H. Birch, J. M. Friedman

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas, but brain tumors are infrequently encountered in adults with NF1. The authors present evidence from two clinical series, one including patients known to have NF1 and another focusing on adults with new onset brain tumors, that suggests an association between NF1 and symptomatic gliomas in older individuals. They also summarize the clinical data on 17 adolescents or adults with NF1 and symptomatic gliomas. The findings suggest that individuals with NF1 are at increased risk of developing gliomas throughout their lives.

Original language	English
Pages (from-to)	759-761
Number of pages	3
Journal	Neurology
Volume	59
Issue number	5
DOIs	https://doi.org/10.1212/WNL.59.5.759
State	Published - Sep 10 2002

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abstract = "Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas, but brain tumors are infrequently encountered in adults with NF1. The authors present evidence from two clinical series, one including patients known to have NF1 and another focusing on adults with new onset brain tumors, that suggests an association between NF1 and symptomatic gliomas in older individuals. They also summarize the clinical data on 17 adolescents or adults with NF1 and symptomatic gliomas. The findings suggest that individuals with NF1 are at increased risk of developing gliomas throughout their lives.",

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AU - Gutmann, D. H.

AU - Rasmussen, S. A.

AU - Wolkenstein, P.

AU - MacCollin, M. M.

AU - Guha, A.

AU - Inskip, P. D.

AU - North, K. N.

AU - Poyhonen, M.

AU - Birch, P. H.

AU - Friedman, J. M.

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N2 - Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas, but brain tumors are infrequently encountered in adults with NF1. The authors present evidence from two clinical series, one including patients known to have NF1 and another focusing on adults with new onset brain tumors, that suggests an association between NF1 and symptomatic gliomas in older individuals. They also summarize the clinical data on 17 adolescents or adults with NF1 and symptomatic gliomas. The findings suggest that individuals with NF1 are at increased risk of developing gliomas throughout their lives.

AB - Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas, but brain tumors are infrequently encountered in adults with NF1. The authors present evidence from two clinical series, one including patients known to have NF1 and another focusing on adults with new onset brain tumors, that suggests an association between NF1 and symptomatic gliomas in older individuals. They also summarize the clinical data on 17 adolescents or adults with NF1 and symptomatic gliomas. The findings suggest that individuals with NF1 are at increased risk of developing gliomas throughout their lives.

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JO - Neurology

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IS - 5

ER -

Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)

Abstract

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