Glia/Astrocytes: Glial-Mediated Mechanisms of Epileptogenesis in Tuberous Sclerosis

L. H. Zeng, D. H. Gutmann, M. Wong

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Patients with tuberous sclerosis complex (TSC) frequently have epilepsy that is poorly responsive to current therapies. To study the role of glia in epileptogenesis in TSC, we generated knockout mice with inactivation of the Tsc1 gene primarily in glia (Tsc1GFAPCKO mice). Tsc1GFAPCKO mice develop spontaneous seizures and exhibit a number of glial abnormalities that may promote epileptogenesis, including astrocyte proliferation, impaired astrocytic regulation of glutamate and potassium transport and homeostasis, and dysregulation of specific intracellular signaling pathways. These findings demonstrate the importance of glial-mediated mechanisms of epileptogenesis and suggest novel therapeutic targets for epilepsy directed at glial defects in TSC.

Original languageEnglish
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Pages391-397
Number of pages7
ISBN (Print)9780123739612
DOIs
StatePublished - Jan 1 2009

Keywords

  • Astrocyte
  • Epilepsy
  • GLAST
  • GLT-1
  • Glia
  • Glutamate
  • Kir
  • MTOR
  • Mouse model
  • Potassium
  • Rapamycin
  • Seizure
  • Tuberous sclerosis complex

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