Gibbs sampling in DP-based nonlinear mixed effects models

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Abstract

This article uses several approaches to deal with the difficulty involved in evaluating the intractable integral when using Gibbs sampling to estimate the nonlinear mixed effects model (NLMM) based on the Dirichlet process (DP). For illustration, we applied these approaches to real data and simulations. Comparisons are then made between these methods with respect to estimation accuracy and computing efficiency.

Original languageEnglish
Pages (from-to)325-340
Number of pages16
JournalJournal of Applied Statistics
Volume37
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Adaptive Gaussian quadrature approximation
  • Dirichlet process
  • EM algorithm
  • Laplace's approximation
  • Markov chain
  • Monte Carlo approximations
  • No-gaps algorithm
  • Nonlinear mixed effects model

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