Abstract
This article uses several approaches to deal with the difficulty involved in evaluating the intractable integral when using Gibbs sampling to estimate the nonlinear mixed effects model (NLMM) based on the Dirichlet process (DP). For illustration, we applied these approaches to real data and simulations. Comparisons are then made between these methods with respect to estimation accuracy and computing efficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 325-340 |
| Number of pages | 16 |
| Journal | Journal of Applied Statistics |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2010 |
Keywords
- Adaptive Gaussian quadrature approximation
- Dirichlet process
- EM algorithm
- Laplace's approximation
- Markov chain
- Monte Carlo approximations
- No-gaps algorithm
- Nonlinear mixed effects model