Giant cell lichenoid dermatitis

Juan G. Gonzalez, Morris D. Marcus, Daniel J. Santa Cruz

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A case of drug-induced lichenoid dermatitis with an unusual epidermotropic multinucleated giant cell inflammatory response is reported. The patient is a 52-year-old white woman who is steroid-dependent because of longstanding systemic lupus erythematosus. At the time of presentation of her generalized papulosquamous pruritic eruption, she was taking oral antihypertensive medications (methyldopa and chlorothiazide). After discontinuation of these medications and local treatment with topical corticosteroids, the skin eruption dramatically improved. Microscopically, the skin lesions had a lichenoid inflammatory pattern, with multiple cytoid bodies, multinucleated giant cells, and a mixed chronic inflammatory infiltrate that included lymphocytes, histiocytes, and eosinophils. (J Am Acad Dermatol 15:87-92, 1986.)

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - Jan 1 1986


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