Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.

Original languageEnglish
Pages (from-to)896-897
Number of pages2
JournalCell metabolism
Issue number6
StatePublished - Jun 3 2014


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