Getting pumped about heart failure

Douglas L. Mann

doi:10.1016/j.cmet.2014.05.008

Getting pumped about heart failure

Douglas L. Mann

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.

Original language	English
Pages (from-to)	896-897
Number of pages	2
Journal	Cell metabolism
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2014.05.008
State	Published - Jun 3 2014

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10.1016/j.cmet.2014.05.008

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title = "Getting pumped about heart failure",

abstract = "Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.",

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year = "2014",

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AU - Mann, Douglas L.

PY - 2014/6/3

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AB - Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.

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DO - 10.1016/j.cmet.2014.05.008

M3 - Short survey

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SN - 1550-4131

VL - 19

SP - 896

EP - 897

JO - Cell metabolism

JF - Cell metabolism

IS - 6

ER -

Getting pumped about heart failure

Abstract

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