Getting a "Hold" on NPC2

Daniel S. Ory

doi:10.1016/j.cmet.2009.08.006

Getting a "Hold" on NPC2

Daniel S. Ory

Division of Cardiology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

Original language	English
Pages (from-to)	161-162
Number of pages	2
Journal	Cell metabolism
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2009.08.006
State	Published - Sep 2 2009

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10.1016/j.cmet.2009.08.006

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AB - Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

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Getting a "Hold" on NPC2

Abstract

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