Getting a "Hold" on NPC2

Daniel S. Ory

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

Original languageEnglish
Pages (from-to)161-162
Number of pages2
JournalCell metabolism
Issue number3
StatePublished - Sep 2 2009


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