Getting a grip on things: How do communities of bacterial symbionts become established in our intestine?

Justin L. Sonnenburg, Largus T. Angenent, Jeffrey I. Gordon

Research output: Contribution to journalReview articlepeer-review

294 Scopus citations

Abstract

The gut contains our largest collection of resident microorganisms. One obvious question is how microbial communities establish and maintain themselves within a perfused intestine. The answers, which may come in part from observations made by environmental engineers and glycobiologists, have important implications for immunologists who wish to understand how indigenous microbial communities are accommodated. Here we propose that the mucus gel layer overlying the intestinal epithelium is a key contributor to the structural and functional stability of this microbiota and its tolerance by the host.

Original languageEnglish
Pages (from-to)569-573
Number of pages5
JournalNature immunology
Volume5
Issue number6
DOIs
StatePublished - Jun 2004

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