Gestational weight gain in insulin-resistant pregnancies

L. M. Harper, A. L. Shanks, A. O. Odibo, R. Colvin, G. A. Macones, A. G. Cahill

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVE:To examine the Institute of Medicine (IOM) guidelines for gestational weight gain (GWG) in insulin-resistant pregnancy.STUDY DESIGN:Secondary analysis of a prospective cohort of 435 women with type 2 or gestational diabetes from 2006 to 2010. The exposure was categorized as GWG less than, within or greater than the IOM recommendations for body mass index. The maternal outcome was a composite of preeclampsia, eclampsia, third- to fourth-degree laceration, readmission or wound infection. The neonatal outcome was a composite of preterm delivery, level 3 nursery admission, oxygen requirement >6 h, shoulder dystocia, 5-min Apgar≤3, umbilical cord arterial pH<7.1 or base excess <-12. Secondary outcomes were cesarean delivery (CD), macrosomia and small for gestational age (SGA).RESULT:Incidence of the maternal outcome did not differ with GWG (P=0.15). Women gaining more than recommended had an increased risk of CD (relative risk (RR) 1.31, 95% confidence interval (CI) 1.01 to 1.69) and the neonatal outcome (RR 1.40, 95% CI 1.01 to 1.95) compared with women gaining within the IOM recommendations. Women gaining less than recommended had an increased risk of SGA (RR 3.29, 95% CI 1.09 to 9.91) without a decrease in the risk of the maternal outcome (RR 0.93, 95% CI 0.49 to 1.78) or CD (RR 0.74, 95% CI 0.40 to 1.37) compared with women gaining within the IOM recommendations.CONCLUSION:Women with insulin resistance should be advised to gain within the current IOM guidelines.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalJournal of Perinatology
Issue number12
StatePublished - Dec 2013


  • gestational diabetes
  • gestational weight gain
  • type 2 diabetes


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