Gestational hyperandrogenism in developmental programming

Christopher Hakim, Vasantha Padmanabhan, Arpita K. Vyas

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.

Original languageEnglish
Pages (from-to)199-212
Number of pages14
Issue number2
StatePublished - Feb 1 2017


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