Gestational growth trajectories derived from a dynamic fetal–placental scaling law

Daniel Baller; Diana M. Thomas; Kevin Cummiskey; Carl Bredlau; Nadav Schwartz; Kelly Orzechowski; Richard C. Miller; Anthony Odibo; Ruchit Shah; Carolyn M. Salafia

doi:10.1098/rsif.2019.0417

Gestational growth trajectories derived from a dynamic fetal–placental scaling law

Daniel Baller, Diana M. Thomas, Kevin Cummiskey, Carl Bredlau, Nadav Schwartz, Kelly Orzechowski, Richard C. Miller, Anthony Odibo, Ruchit Shah, Carolyn M. Salafia

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.

Original language	English
Article number	20190417
Journal	Journal of the Royal Society Interface
Volume	16
Issue number	159
DOIs	https://doi.org/10.1098/rsif.2019.0417
State	Published - Oct 1 2019

Keywords

Differential equation
Fetal growth curves
Logistic growth model
Nonlinear regression
Placenta
Placental volume

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10.1098/rsif.2019.0417

Cite this

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title = "Gestational growth trajectories derived from a dynamic fetal–placental scaling law",

abstract = "Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.",

keywords = "Differential equation, Fetal growth curves, Logistic growth model, Nonlinear regression, Placenta, Placental volume",

author = "Daniel Baller and Thomas, {Diana M.} and Kevin Cummiskey and Carl Bredlau and Nadav Schwartz and Kelly Orzechowski and Miller, {Richard C.} and Anthony Odibo and Ruchit Shah and Salafia, {Carolyn M.}",

note = "Funding Information: D.M.T. and C.M.S. were funded by NIH (grant no. R43 HD066952). Funding Information: D.M.T. and C.M.S. were funded by NIH (grant no. R43 HD066952). Publisher Copyright: {\textcopyright} 2019 The Author(s) Published by the Royal Society. All rights reserved.",

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AU - Baller, Daniel

AU - Thomas, Diana M.

AU - Cummiskey, Kevin

AU - Bredlau, Carl

AU - Schwartz, Nadav

AU - Orzechowski, Kelly

AU - Miller, Richard C.

AU - Odibo, Anthony

AU - Shah, Ruchit

AU - Salafia, Carolyn M.

N1 - Funding Information: D.M.T. and C.M.S. were funded by NIH (grant no. R43 HD066952). Funding Information: D.M.T. and C.M.S. were funded by NIH (grant no. R43 HD066952). Publisher Copyright: © 2019 The Author(s) Published by the Royal Society. All rights reserved.

PY - 2019/10/1

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N2 - Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.

AB - Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.

KW - Differential equation

KW - Fetal growth curves

KW - Logistic growth model

KW - Nonlinear regression

KW - Placenta

KW - Placental volume

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Gestational growth trajectories derived from a dynamic fetal–placental scaling law

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Keywords

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