TY - JOUR
T1 - Geroscience-Centric Perspective for Geriatric Psychiatry
T2 - Integrating Aging Biology With Geriatric Mental Health Research
AU - Diniz, Breno S.
AU - Seitz-Holland, Johanna
AU - Sehgal, Raghav
AU - Kasamoto, Jessica
AU - Higgins-Chen, Albert T.
AU - Lenze, Eric
N1 - Publisher Copyright:
© 2023 American Association for Geriatric Psychiatry
PY - 2024/1
Y1 - 2024/1
N2 - The geroscience hypothesis asserts that physiological aging is caused by a small number of biological pathways. Despite the explosion of geroscience research over the past couple of decades, the research on how serious mental illnesses (SMI) affects the biological aging processes is still in its infancy. In this review, we aim to provide a critical appraisal of the emerging literature focusing on how we measure biological aging systematically, and in the brain and how SMIs affect biological aging measures in older adults. We will also review recent developments in the field of cellular senescence and potential targets for interventions for SMIs in older adults, based on the geroscience hypothesis.
AB - The geroscience hypothesis asserts that physiological aging is caused by a small number of biological pathways. Despite the explosion of geroscience research over the past couple of decades, the research on how serious mental illnesses (SMI) affects the biological aging processes is still in its infancy. In this review, we aim to provide a critical appraisal of the emerging literature focusing on how we measure biological aging systematically, and in the brain and how SMIs affect biological aging measures in older adults. We will also review recent developments in the field of cellular senescence and potential targets for interventions for SMIs in older adults, based on the geroscience hypothesis.
KW - Aging
KW - geroscience
KW - late-life depression
KW - serious mental illnesses
UR - http://www.scopus.com/inward/record.url?scp=85174053601&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2023.09.014
DO - 10.1016/j.jagp.2023.09.014
M3 - Article
C2 - 37845116
AN - SCOPUS:85174053601
SN - 1064-7481
VL - 32
SP - 1
EP - 16
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 1
ER -