Germline predisposition to clonal hematopoiesis

Jie Liu, Afaf E.G. Osman, Kelly Bolton, Lucy A. Godley

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development of CH. DNA variants near TERT, SMC4, KPNA4, IL12A, CD164, and ATM confer the strongest associations. In this review, we discuss our current state of knowledge regarding germline predisposition to CH.

Original languageEnglish
Article number107344
JournalLeukemia Research
StatePublished - Sep 2023


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