TY - JOUR
T1 - Germline predisposition to clonal hematopoiesis
AU - Liu, Jie
AU - Osman, Afaf E.G.
AU - Bolton, Kelly
AU - Godley, Lucy A.
N1 - Funding Information:
All authors conceived the content, wrote, and edited the manuscript.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9
Y1 - 2023/9
N2 - We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development of CH. DNA variants near TERT, SMC4, KPNA4, IL12A, CD164, and ATM confer the strongest associations. In this review, we discuss our current state of knowledge regarding germline predisposition to CH.
AB - We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development of CH. DNA variants near TERT, SMC4, KPNA4, IL12A, CD164, and ATM confer the strongest associations. In this review, we discuss our current state of knowledge regarding germline predisposition to CH.
UR - http://www.scopus.com/inward/record.url?scp=85165134623&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2023.107344
DO - 10.1016/j.leukres.2023.107344
M3 - Review article
C2 - 37421681
AN - SCOPUS:85165134623
SN - 0145-2126
VL - 132
JO - Leukemia Research
JF - Leukemia Research
M1 - 107344
ER -